Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was...

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Veröffentlicht in:	British journal of cancer 2015-03, Vol.112 (5), p.866-873
Hauptverfasser:	Kayser, G, Csanadi, A, Kakanou, S, Prasse, A, Kassem, A, Stickeler, E, Passlick, B, zur Hausen, A
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/67/1612/1350 692/699/67/581 Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Down-Regulation Drug Resistance Epidemiology Female Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Microfilament Proteins - metabolism Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Proteins - metabolism Oncology Prognosis Survival Analysis Tissue Array Analysis
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Zusammenfassung:	Background: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. Material and Methods: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). Results: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung ( P =0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage ( P =0.019) and histological grading ( P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2015.2