Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer

Background: Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial–mesenchymal transition-related biomarker plastin3 ( PLS3 ) in peripheral blood could be a prognostic factor in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2015-04, Vol.112 (9), p.1519-1526
Hauptverfasser:	Ueo, H, Sugimachi, K, Gorges, T M, Bartkowiak, K, Yokobori, T, Müller, V, Shinden, Y, Ueda, M, Mori, M, Kuwano, H, Maehara, Y, Ohno, S, Pantel, K, Mimori, K
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/67/1347 Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Blotting, Western Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Research Case-Control Studies Drug Resistance Epidemiology Epithelial-Mesenchymal Transition Female Follow-Up Studies Humans Lymphatic Metastasis Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - blood Microfilament Proteins - biosynthesis Microfilament Proteins - blood Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Oncology Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1526
container_issue	9
container_start_page	1519
container_title	British journal of cancer
container_volume	112
creator	Ueo, H Sugimachi, K Gorges, T M Bartkowiak, K Yokobori, T Müller, V Shinden, Y Ueda, M Ueo, H Mori, M Kuwano, H Maehara, Y Ohno, S Pantel, K Mimori, K
description	Background: Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial–mesenchymal transition-related biomarker plastin3 ( PLS3 ) in peripheral blood could be a prognostic factor in breast cancer. Methods: We examined PLS3 expression in breast cancer cell lines with epithelial and mesenchymal traits and in circulating tumour cells (CTCs) obtained from the peripheral blood of breast cancer patients. We investigated PLS3 expression in the peripheral blood of 594 patients with breast cancer to evaluate the clinical significance of PLS3 expression. Results: Robust PLS3 expression was observed in different breast cancer cell lines (Hs578t, MCF-7, MDA-MB-468, and MDA-MB-231) as well as in a bone marrow derived cancer cell line (BC-M1). In both the training ( n =298) and validation ( n =296) sets, PLS3 expression was observed in CTCs of patients with breast cancer. PLS3 -positive patients showed significantly poorer overall and disease-free survival than PLS3 -negative patients ( P =0.0001 and 0.003, respectively). Subset analysis revealed that this prognostic biomarker was relevant in patients with stage I–III cancer, particularly in patients with luminal-type and triple-negative-type tumours. Conclusions: These data demonstrated that PLS3 was expressed in CTCs undergoing the epithelial–mesenchymal transition in patients with breast cancer. Furthermore, PLS3 may be an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis.
doi_str_mv	10.1038/bjc.2015.132
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4453677</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3668250761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c604t-d25e1d6af3764a6821544581deafc3d2112946fc3ac36325224a1a6f26a1882b3</originalsourceid><addsrcrecordid>eNptkctv1DAQxi1ERbeFG2dkiQsHsviROM4FCa2gIFXiAmfL60xSL4kd7GQREn88k26pCuLkx_zmm8dHyHPOtpxJ_WZ_cFvBeLXlUjwiG15JUXAt6sdkwxirC9YIdk4ucj7gs2G6fkLORaU1Y5xtyK-dT24Z7OxDT-dljEuiDoahaCH5I7R0GmzGoKQ-U0tDPMJAR5u-QaJdTHRK0Hp3mz3E0BczpBE_Yx9ixgwf6ITaEOZMf_j5hu4ToB51NjhIT8lZZ4cMz-7OS_L1w_svu4_F9eerT7t314VTrJyLVlTAW2U7WavSKi14VZaV5i3YzslWcC6aUuHVOqmkqIQoLbeqE8pyrcVeXpK3J91p2Y_QOmwn2cFMyeMkP0203vwdCf7G9PFosIxUdY0Cr-4EUvy-QJ7N6PO6JhsgLtnwFaqbRpSIvvwHPeBOA463UkqiHtNIvT5RLsWcE3T3zXBmVlsN2mpWWw3aiviLhwPcw398RKA4ARlDoYf0oOr_BH8DPsmupQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1676336708</pqid></control><display><type>article</type><title>Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Ueo, H ; Sugimachi, K ; Gorges, T M ; Bartkowiak, K ; Yokobori, T ; Müller, V ; Shinden, Y ; Ueda, M ; Ueo, H ; Mori, M ; Kuwano, H ; Maehara, Y ; Ohno, S ; Pantel, K ; Mimori, K</creator><creatorcontrib>Ueo, H ; Sugimachi, K ; Gorges, T M ; Bartkowiak, K ; Yokobori, T ; Müller, V ; Shinden, Y ; Ueda, M ; Ueo, H ; Mori, M ; Kuwano, H ; Maehara, Y ; Ohno, S ; Pantel, K ; Mimori, K</creatorcontrib><description>Background: Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial–mesenchymal transition-related biomarker plastin3 ( PLS3 ) in peripheral blood could be a prognostic factor in breast cancer. Methods: We examined PLS3 expression in breast cancer cell lines with epithelial and mesenchymal traits and in circulating tumour cells (CTCs) obtained from the peripheral blood of breast cancer patients. We investigated PLS3 expression in the peripheral blood of 594 patients with breast cancer to evaluate the clinical significance of PLS3 expression. Results: Robust PLS3 expression was observed in different breast cancer cell lines (Hs578t, MCF-7, MDA-MB-468, and MDA-MB-231) as well as in a bone marrow derived cancer cell line (BC-M1). In both the training ( n =298) and validation ( n =296) sets, PLS3 expression was observed in CTCs of patients with breast cancer. PLS3 -positive patients showed significantly poorer overall and disease-free survival than PLS3 -negative patients ( P =0.0001 and 0.003, respectively). Subset analysis revealed that this prognostic biomarker was relevant in patients with stage I–III cancer, particularly in patients with luminal-type and triple-negative-type tumours. Conclusions: These data demonstrated that PLS3 was expressed in CTCs undergoing the epithelial–mesenchymal transition in patients with breast cancer. Furthermore, PLS3 may be an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2015.132</identifier><identifier>PMID: 25880010</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2422 ; 692/699/67/1347 ; Biomarkers, Tumor - blood ; Biomedical and Life Sciences ; Biomedicine ; Blotting, Western ; Breast Neoplasms - blood ; Breast Neoplasms - genetics ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Cancer Research ; Case-Control Studies ; Drug Resistance ; Epidemiology ; Epithelial-Mesenchymal Transition ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - blood ; Microfilament Proteins - biosynthesis ; Microfilament Proteins - blood ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Neoplastic Cells, Circulating - metabolism ; Neoplastic Cells, Circulating - pathology ; Oncology ; Prognosis ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; Survival Rate</subject><ispartof>British journal of cancer, 2015-04, Vol.112 (9), p.1519-1526</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Apr 28, 2015</rights><rights>Copyright © 2015 Cancer Research UK 2015 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-d25e1d6af3764a6821544581deafc3d2112946fc3ac36325224a1a6f26a1882b3</citedby><cites>FETCH-LOGICAL-c604t-d25e1d6af3764a6821544581deafc3d2112946fc3ac36325224a1a6f26a1882b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453677/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453677/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25880010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueo, H</creatorcontrib><creatorcontrib>Sugimachi, K</creatorcontrib><creatorcontrib>Gorges, T M</creatorcontrib><creatorcontrib>Bartkowiak, K</creatorcontrib><creatorcontrib>Yokobori, T</creatorcontrib><creatorcontrib>Müller, V</creatorcontrib><creatorcontrib>Shinden, Y</creatorcontrib><creatorcontrib>Ueda, M</creatorcontrib><creatorcontrib>Ueo, H</creatorcontrib><creatorcontrib>Mori, M</creatorcontrib><creatorcontrib>Kuwano, H</creatorcontrib><creatorcontrib>Maehara, Y</creatorcontrib><creatorcontrib>Ohno, S</creatorcontrib><creatorcontrib>Pantel, K</creatorcontrib><creatorcontrib>Mimori, K</creatorcontrib><title>Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background: Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial–mesenchymal transition-related biomarker plastin3 ( PLS3 ) in peripheral blood could be a prognostic factor in breast cancer. Methods: We examined PLS3 expression in breast cancer cell lines with epithelial and mesenchymal traits and in circulating tumour cells (CTCs) obtained from the peripheral blood of breast cancer patients. We investigated PLS3 expression in the peripheral blood of 594 patients with breast cancer to evaluate the clinical significance of PLS3 expression. Results: Robust PLS3 expression was observed in different breast cancer cell lines (Hs578t, MCF-7, MDA-MB-468, and MDA-MB-231) as well as in a bone marrow derived cancer cell line (BC-M1). In both the training ( n =298) and validation ( n =296) sets, PLS3 expression was observed in CTCs of patients with breast cancer. PLS3 -positive patients showed significantly poorer overall and disease-free survival than PLS3 -negative patients ( P =0.0001 and 0.003, respectively). Subset analysis revealed that this prognostic biomarker was relevant in patients with stage I–III cancer, particularly in patients with luminal-type and triple-negative-type tumours. Conclusions: These data demonstrated that PLS3 was expressed in CTCs undergoing the epithelial–mesenchymal transition in patients with breast cancer. Furthermore, PLS3 may be an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis.</description><subject>692/53/2422</subject><subject>692/699/67/1347</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blotting, Western</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - blood</subject><subject>Microfilament Proteins - biosynthesis</subject><subject>Microfilament Proteins - blood</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Neoplastic Cells, Circulating - metabolism</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Survival Rate</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkctv1DAQxi1ERbeFG2dkiQsHsviROM4FCa2gIFXiAmfL60xSL4kd7GQREn88k26pCuLkx_zmm8dHyHPOtpxJ_WZ_cFvBeLXlUjwiG15JUXAt6sdkwxirC9YIdk4ucj7gs2G6fkLORaU1Y5xtyK-dT24Z7OxDT-dljEuiDoahaCH5I7R0GmzGoKQ-U0tDPMJAR5u-QaJdTHRK0Hp3mz3E0BczpBE_Yx9ixgwf6ITaEOZMf_j5hu4ToB51NjhIT8lZZ4cMz-7OS_L1w_svu4_F9eerT7t314VTrJyLVlTAW2U7WavSKi14VZaV5i3YzslWcC6aUuHVOqmkqIQoLbeqE8pyrcVeXpK3J91p2Y_QOmwn2cFMyeMkP0203vwdCf7G9PFosIxUdY0Cr-4EUvy-QJ7N6PO6JhsgLtnwFaqbRpSIvvwHPeBOA463UkqiHtNIvT5RLsWcE3T3zXBmVlsN2mpWWw3aiviLhwPcw398RKA4ARlDoYf0oOr_BH8DPsmupQ</recordid><startdate>20150428</startdate><enddate>20150428</enddate><creator>Ueo, H</creator><creator>Sugimachi, K</creator><creator>Gorges, T M</creator><creator>Bartkowiak, K</creator><creator>Yokobori, T</creator><creator>Müller, V</creator><creator>Shinden, Y</creator><creator>Ueda, M</creator><creator>Ueo, H</creator><creator>Mori, M</creator><creator>Kuwano, H</creator><creator>Maehara, Y</creator><creator>Ohno, S</creator><creator>Pantel, K</creator><creator>Mimori, K</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150428</creationdate><title>Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer</title><author>Ueo, H ; Sugimachi, K ; Gorges, T M ; Bartkowiak, K ; Yokobori, T ; Müller, V ; Shinden, Y ; Ueda, M ; Ueo, H ; Mori, M ; Kuwano, H ; Maehara, Y ; Ohno, S ; Pantel, K ; Mimori, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-d25e1d6af3764a6821544581deafc3d2112946fc3ac36325224a1a6f26a1882b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/53/2422</topic><topic>692/699/67/1347</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blotting, Western</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - blood</topic><topic>Microfilament Proteins - biosynthesis</topic><topic>Microfilament Proteins - blood</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Neoplastic Cells, Circulating - metabolism</topic><topic>Neoplastic Cells, Circulating - pathology</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueo, H</creatorcontrib><creatorcontrib>Sugimachi, K</creatorcontrib><creatorcontrib>Gorges, T M</creatorcontrib><creatorcontrib>Bartkowiak, K</creatorcontrib><creatorcontrib>Yokobori, T</creatorcontrib><creatorcontrib>Müller, V</creatorcontrib><creatorcontrib>Shinden, Y</creatorcontrib><creatorcontrib>Ueda, M</creatorcontrib><creatorcontrib>Ueo, H</creatorcontrib><creatorcontrib>Mori, M</creatorcontrib><creatorcontrib>Kuwano, H</creatorcontrib><creatorcontrib>Maehara, Y</creatorcontrib><creatorcontrib>Ohno, S</creatorcontrib><creatorcontrib>Pantel, K</creatorcontrib><creatorcontrib>Mimori, K</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueo, H</au><au>Sugimachi, K</au><au>Gorges, T M</au><au>Bartkowiak, K</au><au>Yokobori, T</au><au>Müller, V</au><au>Shinden, Y</au><au>Ueda, M</au><au>Ueo, H</au><au>Mori, M</au><au>Kuwano, H</au><au>Maehara, Y</au><au>Ohno, S</au><au>Pantel, K</au><au>Mimori, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2015-04-28</date><risdate>2015</risdate><volume>112</volume><issue>9</issue><spage>1519</spage><epage>1526</epage><pages>1519-1526</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background: Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial–mesenchymal transition-related biomarker plastin3 ( PLS3 ) in peripheral blood could be a prognostic factor in breast cancer. Methods: We examined PLS3 expression in breast cancer cell lines with epithelial and mesenchymal traits and in circulating tumour cells (CTCs) obtained from the peripheral blood of breast cancer patients. We investigated PLS3 expression in the peripheral blood of 594 patients with breast cancer to evaluate the clinical significance of PLS3 expression. Results: Robust PLS3 expression was observed in different breast cancer cell lines (Hs578t, MCF-7, MDA-MB-468, and MDA-MB-231) as well as in a bone marrow derived cancer cell line (BC-M1). In both the training ( n =298) and validation ( n =296) sets, PLS3 expression was observed in CTCs of patients with breast cancer. PLS3 -positive patients showed significantly poorer overall and disease-free survival than PLS3 -negative patients ( P =0.0001 and 0.003, respectively). Subset analysis revealed that this prognostic biomarker was relevant in patients with stage I–III cancer, particularly in patients with luminal-type and triple-negative-type tumours. Conclusions: These data demonstrated that PLS3 was expressed in CTCs undergoing the epithelial–mesenchymal transition in patients with breast cancer. Furthermore, PLS3 may be an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25880010</pmid><doi>10.1038/bjc.2015.132</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0007-0920
ispartof	British journal of cancer, 2015-04, Vol.112 (9), p.1519-1526
issn	0007-0920 1532-1827
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4453677
source	MEDLINE; SpringerLink Journals; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects	692/53/2422 692/699/67/1347 Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Blotting, Western Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Research Case-Control Studies Drug Resistance Epidemiology Epithelial-Mesenchymal Transition Female Follow-Up Studies Humans Lymphatic Metastasis Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - blood Microfilament Proteins - biosynthesis Microfilament Proteins - blood Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Oncology Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate
title	Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T06%3A14%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20tumour%20cell-derived%20plastin3%20is%20a%20novel%20marker%20for%20predicting%20long-term%20prognosis%20in%20patients%20with%20breast%20cancer&rft.jtitle=British%20journal%20of%20cancer&rft.au=Ueo,%20H&rft.date=2015-04-28&rft.volume=112&rft.issue=9&rft.spage=1519&rft.epage=1526&rft.pages=1519-1526&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/bjc.2015.132&rft_dat=%3Cproquest_pubme%3E3668250761%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1676336708&rft_id=info:pmid/25880010&rfr_iscdi=true