PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis

Elucidating mechanisms of hepatitis B virus (HBV)-mediated hepatocarcinogenesis is needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is replicating exhibit increased expression of Plk1 kinase and reduced levels of two transcription repression factors, SUZ12 and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-06, Vol.75 (11), p.2363-2374
Hauptverfasser:	Zhang, Hao, Diab, Ahmed, Fan, Huitao, Mani, Saravana Kumar Kailasam, Hullinger, Ronald, Merle, Philippe, Andrisani, Ourania
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell Transformation, Neoplastic - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Epigenesis, Genetic - genetics Hepatitis B - virology Hepatitis B virus - pathogenicity Hepatocytes - metabolism Hepatocytes - pathology Humans Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - virology Mice Neoplasm Proteins Polo-Like Kinase 1 Polycomb Repressive Complex 2 - biosynthesis Polycomb Repressive Complex 2 - genetics Promoter Regions, Genetic Protein Serine-Threonine Kinases - biosynthesis Protein Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics Transcription Factors - biosynthesis Transcription Factors - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!