Cadmium‐coordinated supramolecule suppresses tumor growth of T‐cell leukemia in mice

Cadmium is a toxic pollutant with occupational and environmental significance, due to its diverse toxic effects. Supramolecules that conjugate and decontaminate toxic metals have potential for use in treatment of cadmium intoxication. In addition, metal‐coordinating ability has been postulated to co...

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Veröffentlicht in:	Cancer science 2015-05, Vol.106 (5), p.635-641
Hauptverfasser:	Zhou, Xiaoping, Koizumi, Yukio, Zhang, Muxin, Natsui, Miyuki, Koyota, Souichi, Yamada, Manabu, Kondo, Yoshihiko, Hamada, Fumio, Sugiyama, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological activity Bleomycin Cadmium Cadmium - pharmacokinetics Cadmium - toxicity Cadmium Compounds - pharmacology Caspase Cell activation Cell death Cell Line, Tumor Cell Proliferation - drug effects Cisplatin Coordination Complexes - chemistry Coordination Complexes - pharmacology Cytotoxicity Dehydrogenases Female Heavy metals Humans Inhibitory Concentration 50 Intoxication Jurkat Cells - drug effects Kidneys Leukemia Leukemia, T-Cell - drug therapy Leukemia, T-Cell - pathology Liver Metal ions Mice, SCID Original Phenols - chemistry Phenols - pharmacology Pollutants Sulfur supramolecule thiacalixarene Tumor cell lines T‐cell receptor Xenograft Model Antitumor Assays Xenografts
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