The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

Inhibition of T cell–derived leukocyte elastase by neuronal SerpinA3N or the drug Sivelestat reduces neuropathic pain. Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identifi...

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Veröffentlicht in:	Nature medicine 2015-05, Vol.21 (5), p.518-523
Hauptverfasser:	Vicuña, Lucas, Strochlic, David E, Latremoliere, Alban, Bali, Kiran Kumar, Simonetti, Manuela, Husainie, Dewi, Prokosch, Sandra, Riva, Priscilla, Griffin, Robert S, Njoo, Christian, Gehrig, Stefanie, Mall, Marcus A, Arnold, Bernd, Devor, Marshall, Woolf, Clifford J, Liberles, Stephen D, Costigan, Michael, Kuner, Rohini
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 42/41 64/60 692/308/2778 Acute-Phase Proteins - metabolism Animals Biomedicine Cancer Research Care and treatment Cell Separation Dependovirus - genetics Enzyme inhibitors Enzyme Inhibitors - pharmacology Female Ganglia, Spinal - metabolism Health aspects Hyperalgesia - physiopathology Hypersensitivity Immune response In Situ Hybridization Infectious Diseases letter Leukocyte Elastase - antagonists & inhibitors Lymphocytes Male Metabolic Diseases Mice Mice, Transgenic Molecular Medicine Neuralgia Neurons - metabolism Neurosciences Oligonucleotide Array Sequence Analysis Pain Pain - physiopathology Phenotype Polymerase Chain Reaction Proteinase inhibitors Rats Selective breeding Serpins - metabolism T-Lymphocytes - cytology Up-Regulation
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