The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

Intestinal epithelial cell (IEC) death is typical of inflammatory bowel disease (IBD). We investigated: i) whether IEC–released necrotic cell products (proinflammatory mediators) amplify mucosal inflammation, ii) the capacity of necrotic cell lysates from HT29 cells or human IECs to induce human int...

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Veröffentlicht in:The American journal of pathology 2015-06, Vol.185 (6), p.1624-1637
Hauptverfasser: Scarpa, Melania, Kessler, Sean, Sadler, Tammy, West, Gail, Homer, Craig, McDonald, Christine, de la Motte, Carol, Fiocchi, Claudio, Stylianou, Eleni
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Sprache:eng
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