How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-11 |
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| creator | Penha-Gonçalves, Carlos Almeida, Joana I. Patarrão, Rita S. Coelho, Inês C. Duarte, Nádia Macedo, M. Paula |
| description | Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD. |
| doi_str_mv | 10.1155/2015/984578 |
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Paula</creator><contributor>Collado, Maria Carmen</contributor><creatorcontrib>Penha-Gonçalves, Carlos ; Almeida, Joana I. ; Patarrão, Rita S. ; Coelho, Inês C. ; Duarte, Nádia ; Macedo, M. Paula ; Collado, Maria Carmen</creatorcontrib><description>Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/984578</identifier><identifier>PMID: 26090470</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Autophagy ; Carbohydrates ; Diabetes ; Diet ; Disease ; Fatty liver ; Humans ; Inflammation ; Inflammation - metabolism ; Inflammation - physiopathology ; Insulin Resistance ; Kupffer Cells - metabolism ; Kupffer Cells - pathology ; Lipids ; Liver ; Liver - metabolism ; Liver - pathology ; Metabolism ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - physiopathology ; Obesity - metabolism ; Obesity - physiopathology ; Pathogenesis ; Physiological aspects ; Population ; Review ; Risk Factors ; Rodents ; Studies ; Triglycerides</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-11</ispartof><rights>Copyright © 2015 Nádia Duarte et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Nadia Duarte et al. Nadia Duarte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Nádia Duarte et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-a75e05e4a28c3e881c93e997e563ff1e59de06ccd070fa28ece8130fa9d1486c3</citedby><cites>FETCH-LOGICAL-c620t-a75e05e4a28c3e881c93e997e563ff1e59de06ccd070fa28ece8130fa9d1486c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450298/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450298/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26090470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Collado, Maria Carmen</contributor><creatorcontrib>Penha-Gonçalves, Carlos</creatorcontrib><creatorcontrib>Almeida, Joana I.</creatorcontrib><creatorcontrib>Patarrão, Rita S.</creatorcontrib><creatorcontrib>Coelho, Inês C.</creatorcontrib><creatorcontrib>Duarte, Nádia</creatorcontrib><creatorcontrib>Macedo, M. Paula</creatorcontrib><title>How Inflammation Impinges on NAFLD: A Role for Kupffer Cells</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.</description><subject>Autophagy</subject><subject>Carbohydrates</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Disease</subject><subject>Fatty liver</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - physiopathology</subject><subject>Insulin Resistance</subject><subject>Kupffer Cells - metabolism</subject><subject>Kupffer Cells - pathology</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Metabolism</subject><subject>Non-alcoholic Fatty Liver Disease - metabolism</subject><subject>Non-alcoholic Fatty Liver Disease - physiopathology</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Studies</subject><subject>Triglycerides</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0c1rFDEYBvBBFFtqT95lwIsoa_M9iYiwrNYuLgqi5xAzb7YpM8k22bH43_suW9fqqbnkhfx4SPI0zVNKXlMq5RkjVJ4ZLWSnHzTHjFMxU1TQh4eZ86PmtNYrgktTRYx63Bwx3InoyHHz9iLftMsUBjeObhtzapfjJqY11Bbnz_Pz1fs37bz9mgdoQy7tp2kTApR2AcNQnzSPghsqnN7uJ8338w_fFhez1ZePy8V8NfOKke3MdRKIBOGY9hy0pt5wMKYDqXgIFKTpgSjve9KRgAg8aMpxND0VWnl-0rzb526mHyP0HtK2uMFuShxd-WWzi_bfkxQv7Tr_tEJIwozGgBe3ASVfT1C3dozV4xNcgjxVS5WhTAvBzH0oYVQILZA-_49e5akk_AlUmCZYR9RftXYD2JhCxiv6XaidC4mVCEokqld75UuutUA4vI4Su2va7pq2-6ZRP7v7IQf7p1cEL_fgMqbe3cT7pQESCO4Olh0WwH8D_xq13Q</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Penha-Gonçalves, Carlos</creator><creator>Almeida, Joana I.</creator><creator>Patarrão, Rita S.</creator><creator>Coelho, Inês C.</creator><creator>Duarte, Nádia</creator><creator>Macedo, M. 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The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26090470</pmid><doi>10.1155/2015/984578</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autophagy Carbohydrates Diabetes Diet Disease Fatty liver Humans Inflammation Inflammation - metabolism Inflammation - physiopathology Insulin Resistance Kupffer Cells - metabolism Kupffer Cells - pathology Lipids Liver Liver - metabolism Liver - pathology Metabolism Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - physiopathology Obesity - metabolism Obesity - physiopathology Pathogenesis Physiological aspects Population Review Risk Factors Rodents Studies Triglycerides |
| title | How Inflammation Impinges on NAFLD: A Role for Kupffer Cells |
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