Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease
We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD). We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New Orle...
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| Veröffentlicht in: | BMC nephrology 2015-05, Vol.16 (1), p.77-77, Article 77 |
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| creator | Lee, Belinda T Ahmed, Faheemuddin A Hamm, L Lee Teran, Federico J Chen, Chung-Shiuan Liu, Yanxi Shah, Kamal Rifai, Nader Batuman, Vecihi Simon, Eric E He, Jiang Chen, Jing |
| description | We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).
We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New Orleans area. CKD was defined as estimated-glomerular filtration rate (eGFR) |
| doi_str_mv | 10.1186/s12882-015-0068-7 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4449580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541395602</galeid><sourcerecordid>A541395602</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-fbe75c16417ba5849ffc91233a9993bbff97389473bce04205def07ffeeea8fb3</originalsourceid><addsrcrecordid>eNptkU1rFTEUhgdRbK3-ADcScOOiqcnkeyNcLn5BwY2uQyZz0hs7k1yTmZb-e3O5tbQgWZyQ87wvOeftureUXFCq5cdKe617TKjAhEiN1bPulHJFcc-kef7oftK9qvU3IVRpTl52J70kvaCmP-3mTa3ZR7fEnFAOaIsLOL_EG0D7kheI6Rwt65wLSuBLrrGi0Pq5YDftd-4cuTSimBYoE6zXMWGJbuOyQ35XcooeXccxwR0aYwVX4XX3Iripwpv7etb9-vL55_Ybvvzx9ft2c4k9M3LBYQAlPJWcqsEJzU0I3tCeMWeMYcMQglFMG67Y4IHwnogRAlEhAIDTYWBn3aej734dZhg9pKW4ye5LnF25s9lF-7ST4s5e5RvLOTdCk2bw4d6g5D8r1MXOsXqYJpcgr9VSqYXiXArd0PdH9MpNYGMKuTn6A243glNmRFt2oy7-Q7Uzwhx9ThBie38ioEfBYeu1QHj4PSX2kL49pm9b-vaQvlVN8-7x2A-Kf3GzvybHrFs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685744658</pqid></control><display><type>article</type><title>Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink (Online service)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Lee, Belinda T ; Ahmed, Faheemuddin A ; Hamm, L Lee ; Teran, Federico J ; Chen, Chung-Shiuan ; Liu, Yanxi ; Shah, Kamal ; Rifai, Nader ; Batuman, Vecihi ; Simon, Eric E ; He, Jiang ; Chen, Jing</creator><creatorcontrib>Lee, Belinda T ; Ahmed, Faheemuddin A ; Hamm, L Lee ; Teran, Federico J ; Chen, Chung-Shiuan ; Liu, Yanxi ; Shah, Kamal ; Rifai, Nader ; Batuman, Vecihi ; Simon, Eric E ; He, Jiang ; Chen, Jing</creatorcontrib><description>We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).
We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New Orleans area. CKD was defined as estimated-glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or albuminuria ≥30 mg/24-h. Serum CRP, TNF-α, and IL-6 were measured using standard methods. Multivariable regression models were used to examine associations between the inflammatory biomarkers and CKD adjusting for important CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.
The multivariable-adjusted medians (interquartile-range) were 2.91 (1.47, 5.24) mg/L in patients with CKD vs. 1.91 (0.99, 3.79) mg/L in controls without CKD (p = 0.39 for group difference) for CRP; 1.86 (1.51, 2.63) pg/mL vs. 1.26 (1.01, 1.98) pg/mL (p < 0.0001) for TNF-α; and 2.53 (1.49, 4.42) pg/mL vs. 1.39 (0.95, 2.15) pg/mL (p = 0.04) for IL-6, respectively. Compared to the lowest tertile, the highest tertile of TNF-α (OR 7.1, 95% CI 3.2 to 15.5) and IL-6 (OR 2.5, 95% CI 1.1 to 5.5) were significantly associated with higher odds of CKD in multivariable-adjusted models. Additionally, higher TNF-α and IL-6 were independently and significantly associated with lower eGFR and higher albuminuria.
Our data suggest that TNF-α and IL-6, but not CRP, are associated with the prevalence and severity of CKD, independent from established CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.</description><identifier>ISSN: 1471-2369</identifier><identifier>EISSN: 1471-2369</identifier><identifier>DOI: 10.1186/s12882-015-0068-7</identifier><identifier>PMID: 26025192</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aged ; Albuminuria - blood ; Analysis ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Cardiovascular diseases ; Care and treatment ; Case-Control Studies ; Complications and side effects ; Creatinine - blood ; Female ; Glomerular Filtration Rate ; Humans ; Inflammation ; Interleukin-6 - blood ; Logistic Models ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Multivariate Analysis ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - physiopathology ; Risk factors ; Severity of Illness Index ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>BMC nephrology, 2015-05, Vol.16 (1), p.77-77, Article 77</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Lee et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-fbe75c16417ba5849ffc91233a9993bbff97389473bce04205def07ffeeea8fb3</citedby><cites>FETCH-LOGICAL-c396t-fbe75c16417ba5849ffc91233a9993bbff97389473bce04205def07ffeeea8fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449580/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449580/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26025192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Belinda T</creatorcontrib><creatorcontrib>Ahmed, Faheemuddin A</creatorcontrib><creatorcontrib>Hamm, L Lee</creatorcontrib><creatorcontrib>Teran, Federico J</creatorcontrib><creatorcontrib>Chen, Chung-Shiuan</creatorcontrib><creatorcontrib>Liu, Yanxi</creatorcontrib><creatorcontrib>Shah, Kamal</creatorcontrib><creatorcontrib>Rifai, Nader</creatorcontrib><creatorcontrib>Batuman, Vecihi</creatorcontrib><creatorcontrib>Simon, Eric E</creatorcontrib><creatorcontrib>He, Jiang</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><title>Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease</title><title>BMC nephrology</title><addtitle>BMC Nephrol</addtitle><description>We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).
We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New Orleans area. CKD was defined as estimated-glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or albuminuria ≥30 mg/24-h. Serum CRP, TNF-α, and IL-6 were measured using standard methods. Multivariable regression models were used to examine associations between the inflammatory biomarkers and CKD adjusting for important CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.
The multivariable-adjusted medians (interquartile-range) were 2.91 (1.47, 5.24) mg/L in patients with CKD vs. 1.91 (0.99, 3.79) mg/L in controls without CKD (p = 0.39 for group difference) for CRP; 1.86 (1.51, 2.63) pg/mL vs. 1.26 (1.01, 1.98) pg/mL (p < 0.0001) for TNF-α; and 2.53 (1.49, 4.42) pg/mL vs. 1.39 (0.95, 2.15) pg/mL (p = 0.04) for IL-6, respectively. Compared to the lowest tertile, the highest tertile of TNF-α (OR 7.1, 95% CI 3.2 to 15.5) and IL-6 (OR 2.5, 95% CI 1.1 to 5.5) were significantly associated with higher odds of CKD in multivariable-adjusted models. Additionally, higher TNF-α and IL-6 were independently and significantly associated with lower eGFR and higher albuminuria.
Our data suggest that TNF-α and IL-6, but not CRP, are associated with the prevalence and severity of CKD, independent from established CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.</description><subject>Adult</subject><subject>Aged</subject><subject>Albuminuria - blood</subject><subject>Analysis</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-6 - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>1471-2369</issn><issn>1471-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1rFTEUhgdRbK3-ADcScOOiqcnkeyNcLn5BwY2uQyZz0hs7k1yTmZb-e3O5tbQgWZyQ87wvOeftureUXFCq5cdKe617TKjAhEiN1bPulHJFcc-kef7oftK9qvU3IVRpTl52J70kvaCmP-3mTa3ZR7fEnFAOaIsLOL_EG0D7kheI6Rwt65wLSuBLrrGi0Pq5YDftd-4cuTSimBYoE6zXMWGJbuOyQ35XcooeXccxwR0aYwVX4XX3Iripwpv7etb9-vL55_Ybvvzx9ft2c4k9M3LBYQAlPJWcqsEJzU0I3tCeMWeMYcMQglFMG67Y4IHwnogRAlEhAIDTYWBn3aej734dZhg9pKW4ye5LnF25s9lF-7ST4s5e5RvLOTdCk2bw4d6g5D8r1MXOsXqYJpcgr9VSqYXiXArd0PdH9MpNYGMKuTn6A243glNmRFt2oy7-Q7Uzwhx9ThBie38ioEfBYeu1QHj4PSX2kL49pm9b-vaQvlVN8-7x2A-Kf3GzvybHrFs</recordid><startdate>20150530</startdate><enddate>20150530</enddate><creator>Lee, Belinda T</creator><creator>Ahmed, Faheemuddin A</creator><creator>Hamm, L Lee</creator><creator>Teran, Federico J</creator><creator>Chen, Chung-Shiuan</creator><creator>Liu, Yanxi</creator><creator>Shah, Kamal</creator><creator>Rifai, Nader</creator><creator>Batuman, Vecihi</creator><creator>Simon, Eric E</creator><creator>He, Jiang</creator><creator>Chen, Jing</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150530</creationdate><title>Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease</title><author>Lee, Belinda T ; Ahmed, Faheemuddin A ; Hamm, L Lee ; Teran, Federico J ; Chen, Chung-Shiuan ; Liu, Yanxi ; Shah, Kamal ; Rifai, Nader ; Batuman, Vecihi ; Simon, Eric E ; He, Jiang ; Chen, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-fbe75c16417ba5849ffc91233a9993bbff97389473bce04205def07ffeeea8fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albuminuria - blood</topic><topic>Analysis</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-6 - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Belinda T</creatorcontrib><creatorcontrib>Ahmed, Faheemuddin A</creatorcontrib><creatorcontrib>Hamm, L Lee</creatorcontrib><creatorcontrib>Teran, Federico J</creatorcontrib><creatorcontrib>Chen, Chung-Shiuan</creatorcontrib><creatorcontrib>Liu, Yanxi</creatorcontrib><creatorcontrib>Shah, Kamal</creatorcontrib><creatorcontrib>Rifai, Nader</creatorcontrib><creatorcontrib>Batuman, Vecihi</creatorcontrib><creatorcontrib>Simon, Eric E</creatorcontrib><creatorcontrib>He, Jiang</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Belinda T</au><au>Ahmed, Faheemuddin A</au><au>Hamm, L Lee</au><au>Teran, Federico J</au><au>Chen, Chung-Shiuan</au><au>Liu, Yanxi</au><au>Shah, Kamal</au><au>Rifai, Nader</au><au>Batuman, Vecihi</au><au>Simon, Eric E</au><au>He, Jiang</au><au>Chen, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease</atitle><jtitle>BMC nephrology</jtitle><addtitle>BMC Nephrol</addtitle><date>2015-05-30</date><risdate>2015</risdate><volume>16</volume><issue>1</issue><spage>77</spage><epage>77</epage><pages>77-77</pages><artnum>77</artnum><issn>1471-2369</issn><eissn>1471-2369</eissn><abstract>We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).
We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New Orleans area. CKD was defined as estimated-glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or albuminuria ≥30 mg/24-h. Serum CRP, TNF-α, and IL-6 were measured using standard methods. Multivariable regression models were used to examine associations between the inflammatory biomarkers and CKD adjusting for important CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.
The multivariable-adjusted medians (interquartile-range) were 2.91 (1.47, 5.24) mg/L in patients with CKD vs. 1.91 (0.99, 3.79) mg/L in controls without CKD (p = 0.39 for group difference) for CRP; 1.86 (1.51, 2.63) pg/mL vs. 1.26 (1.01, 1.98) pg/mL (p < 0.0001) for TNF-α; and 2.53 (1.49, 4.42) pg/mL vs. 1.39 (0.95, 2.15) pg/mL (p = 0.04) for IL-6, respectively. Compared to the lowest tertile, the highest tertile of TNF-α (OR 7.1, 95% CI 3.2 to 15.5) and IL-6 (OR 2.5, 95% CI 1.1 to 5.5) were significantly associated with higher odds of CKD in multivariable-adjusted models. Additionally, higher TNF-α and IL-6 were independently and significantly associated with lower eGFR and higher albuminuria.
Our data suggest that TNF-α and IL-6, but not CRP, are associated with the prevalence and severity of CKD, independent from established CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26025192</pmid><doi>10.1186/s12882-015-0068-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Albuminuria - blood Analysis Biomarkers - blood C-Reactive Protein - metabolism Cardiovascular diseases Care and treatment Case-Control Studies Complications and side effects Creatinine - blood Female Glomerular Filtration Rate Humans Inflammation Interleukin-6 - blood Logistic Models Male Medical research Medicine, Experimental Middle Aged Multivariate Analysis Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - physiopathology Risk factors Severity of Illness Index Tumor Necrosis Factor-alpha - blood Young Adult |
| title | Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease |
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