AKT Pathway Affects Bone Regeneration in Nonunion Treated with Umbilical Cord-Derived Mesenchymal Stem Cells

We have previously grafted human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) with blood plasma to treat rat tibia nonunion. To further examine the biological characteristics of this process, we applied an established hUC-MSCs-treated rat nonunion model with the addition of an inhibitor...

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Veröffentlicht in:	Cell biochemistry and biophysics 2015-04, Vol.71 (3), p.1543-1551
Hauptverfasser:	Qu, Zhiguo, Guo, Shengnan, Fang, Guojun, Cui, Zhenghong, Liu, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Biochemistry Biological and Medical Physics Biomechanical Phenomena - drug effects Biomedical and Life Sciences Biophysics Biotechnology Bone Regeneration - drug effects Cell Adhesion Cell Biology Cell Differentiation Enzyme Inhibitors - pharmacology Gene Expression Regulation, Enzymologic - drug effects Humans Life Sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Original Paper Osteogenesis - drug effects Pharmacology/Toxicology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Stem cells Tibial Fractures - pathology Tibial Fractures - physiopathology Tibial Fractures - surgery Umbilical Cord - cytology
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