Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry
Prior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry o...
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| Veröffentlicht in: | European heart journal cardiovascular imaging 2015-05, Vol.16 (5), p.490-499 |
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| creator | Otaki, Yuka Gransar, Heidi Cheng, Victor Y Dey, Damini Labounty, Troy Lin, Fay Y Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J Cademartiri, Filippo Callister, Tracy Q Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin J W Delago, Augustin Hadamitzky, Martin Hausleiter, Joerg Kaufmann, Philipp Maffei, Erica Raff, Gilbert Shaw, Leslee J Villines, Todd C Dunning, Allison Cury, Ricardo C Feuchtner, Gudrun Kim, Yong-Jin Leipsic, Jonathon Berman, Daniel S Min, James K |
| description | Prior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry of consecutive young individuals undergoing coronary computerized tomographic angiography (CCTA).
Of 27 125 patients undergoing CCTA, 1635 young ( |
| doi_str_mv | 10.1093/ehjci/jeu281 |
| format | Article |
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Of 27 125 patients undergoing CCTA, 1635 young (<45 years) individuals without known coronary artery disease (CAD) or coronary anomalies were identified. Coronary plaque was assessed for any CAD, obstructive CAD (≥50% stenosis), and presence of calcified plaque (CP) and non-calcified plaque (NCP). Among 1635 subjects (70% men, age 38 ± 6 years), any CAD, obstructive CAD, CP, and NCP were observed in 19, 4, 5, and 8%, respectively. Compared with women, men demonstrated higher rates of any CAD (21 vs. 12%, P < 0.001), CP (6 vs. 3%, P = 0.01), and NCP (9 vs. 5%, P = 0.008), although no difference was observed for rates of obstructive CAD (5 vs. 4%, P = 0.46). Any CAD, obstructive CAD, and NCP were higher for young individuals with diabetes, hypertension, dyslipidaemia, current smoking, or family history of CAD; while only diabetes and dyslipidaemia were associated with CP. Increasing cardiovascular RFs was associated with a greater prevalence and extent and severity of CAD, with individuals with 0, 1, 2, ≥3 RFs manifesting a dose-response increase in any CAD (P < 0.001, for trend), obstructive CAD (P < 0.001, for trend), NCP (P < 0.001, for trend), and CP (P < 0.001, for trend). In multivariable analysis adjusting for sex and cardiovascular RFs, male sex was the strongest predictor for any CAD (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.43-2.66, P < 0.001), CP (OR = 1.46, 95% CI = 1.08-1.98, P = 0.01), and NCP (OR = 1.33, 95% CI = 1.06-1.67, P = 0.01); family history of CAD was the strongest predictor for obstructive CAD (OR = 2.71, 95% CI = 1.65-4.45, P < 0.001).
Any and obstructive CAD is present in 1 in 5 and 1 in 20 young individuals, respectively, with family history associated with the greatest risk of obstructive CAD.]]></description><identifier>ISSN: 2047-2404</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jeu281</identifier><identifier>PMID: 25539786</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Coronary Angiography ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Original ; Prevalence ; Prospective Studies ; Registries ; Risk Factors ; Severity of Illness Index ; Sex Factors ; Tomography, X-Ray Computed</subject><ispartof>European heart journal cardiovascular imaging, 2015-05, Vol.16 (5), p.490-499</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2291-b3fb5ef156889a3578ad62e8a44be4aed05961725759c07930cab453aa5aefc43</citedby><cites>FETCH-LOGICAL-c2291-b3fb5ef156889a3578ad62e8a44be4aed05961725759c07930cab453aa5aefc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25539786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otaki, Yuka</creatorcontrib><creatorcontrib>Gransar, Heidi</creatorcontrib><creatorcontrib>Cheng, Victor Y</creatorcontrib><creatorcontrib>Dey, Damini</creatorcontrib><creatorcontrib>Labounty, Troy</creatorcontrib><creatorcontrib>Lin, Fay Y</creatorcontrib><creatorcontrib>Achenbach, Stephan</creatorcontrib><creatorcontrib>Al-Mallah, Mouaz</creatorcontrib><creatorcontrib>Budoff, Matthew J</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><creatorcontrib>Callister, Tracy Q</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><creatorcontrib>Chinnaiyan, Kavitha</creatorcontrib><creatorcontrib>Chow, Benjamin J W</creatorcontrib><creatorcontrib>Delago, Augustin</creatorcontrib><creatorcontrib>Hadamitzky, Martin</creatorcontrib><creatorcontrib>Hausleiter, Joerg</creatorcontrib><creatorcontrib>Kaufmann, Philipp</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Raff, Gilbert</creatorcontrib><creatorcontrib>Shaw, Leslee J</creatorcontrib><creatorcontrib>Villines, Todd C</creatorcontrib><creatorcontrib>Dunning, Allison</creatorcontrib><creatorcontrib>Cury, Ricardo C</creatorcontrib><creatorcontrib>Feuchtner, Gudrun</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Berman, Daniel S</creatorcontrib><creatorcontrib>Min, James K</creatorcontrib><title>Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry</title><title>European heart journal cardiovascular imaging</title><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><description><![CDATA[Prior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry of consecutive young individuals undergoing coronary computerized tomographic angiography (CCTA).
Of 27 125 patients undergoing CCTA, 1635 young (<45 years) individuals without known coronary artery disease (CAD) or coronary anomalies were identified. Coronary plaque was assessed for any CAD, obstructive CAD (≥50% stenosis), and presence of calcified plaque (CP) and non-calcified plaque (NCP). Among 1635 subjects (70% men, age 38 ± 6 years), any CAD, obstructive CAD, CP, and NCP were observed in 19, 4, 5, and 8%, respectively. Compared with women, men demonstrated higher rates of any CAD (21 vs. 12%, P < 0.001), CP (6 vs. 3%, P = 0.01), and NCP (9 vs. 5%, P = 0.008), although no difference was observed for rates of obstructive CAD (5 vs. 4%, P = 0.46). Any CAD, obstructive CAD, and NCP were higher for young individuals with diabetes, hypertension, dyslipidaemia, current smoking, or family history of CAD; while only diabetes and dyslipidaemia were associated with CP. Increasing cardiovascular RFs was associated with a greater prevalence and extent and severity of CAD, with individuals with 0, 1, 2, ≥3 RFs manifesting a dose-response increase in any CAD (P < 0.001, for trend), obstructive CAD (P < 0.001, for trend), NCP (P < 0.001, for trend), and CP (P < 0.001, for trend). In multivariable analysis adjusting for sex and cardiovascular RFs, male sex was the strongest predictor for any CAD (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.43-2.66, P < 0.001), CP (OR = 1.46, 95% CI = 1.08-1.98, P = 0.01), and NCP (OR = 1.33, 95% CI = 1.06-1.67, P = 0.01); family history of CAD was the strongest predictor for obstructive CAD (OR = 2.71, 95% CI = 1.65-4.45, P < 0.001).
Any and obstructive CAD is present in 1 in 5 and 1 in 20 young individuals, respectively, with family history associated with the greatest risk of obstructive CAD.]]></description><subject>Adult</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Original</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>2047-2404</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUsFu1DAQjRCIVqU3zshHDrs0ju044YCEVlCQKnEpZ2viTLJeJXawnZXyr_0YHHa7gC9je968eTN6WfaW5h9oXrM73B-0uTvgXFT0RXZd5FxuC06Ll5d7zq-y2xAOeTqCl7ygr7OrQghWy6q8zp7u0bboSWu6Dj1ajYEYS-IeyeTxCMP6tSEBj-hNXDYEbEu0GycXTDTOEtelp3cW_ELAR0yhNQEh4DPP4mbbfyRAQpzbZS2gJRMp25qjaWcYAplXDb0ztv9LtntMvXrjeg_TfiGdd-NZlgsT6miOSdc4D9FYWJXAkGptZ_xIPPYmRL-8yV51iR5vz_Em-_n1y-Pu2_bhx_333eeHrS6Kmm4b1jUCOyrKqqqBCVlBWxZYAecNcsA2F3VJZSGkqHUua5ZraLhgAAKw05zdZJ9OvNPcjNhqtNHDoCZvxjSJcmDU_xlr9qp3R8U5l1KyRPD-TODdrxlDVKMJGocBLLo5KFpKUZV1ndME3ZygOu0heOwubWiuVk-oP55QJ08k-Lt_pV3Azw5gvwEuP7tN</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Otaki, Yuka</creator><creator>Gransar, Heidi</creator><creator>Cheng, Victor Y</creator><creator>Dey, Damini</creator><creator>Labounty, Troy</creator><creator>Lin, Fay Y</creator><creator>Achenbach, Stephan</creator><creator>Al-Mallah, Mouaz</creator><creator>Budoff, Matthew J</creator><creator>Cademartiri, Filippo</creator><creator>Callister, Tracy Q</creator><creator>Chang, Hyuk-Jae</creator><creator>Chinnaiyan, Kavitha</creator><creator>Chow, Benjamin J W</creator><creator>Delago, Augustin</creator><creator>Hadamitzky, Martin</creator><creator>Hausleiter, Joerg</creator><creator>Kaufmann, Philipp</creator><creator>Maffei, Erica</creator><creator>Raff, Gilbert</creator><creator>Shaw, Leslee J</creator><creator>Villines, Todd C</creator><creator>Dunning, Allison</creator><creator>Cury, Ricardo C</creator><creator>Feuchtner, Gudrun</creator><creator>Kim, Yong-Jin</creator><creator>Leipsic, Jonathon</creator><creator>Berman, Daniel S</creator><creator>Min, James K</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201505</creationdate><title>Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry</title><author>Otaki, Yuka ; Gransar, Heidi ; Cheng, Victor Y ; Dey, Damini ; Labounty, Troy ; Lin, Fay Y ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Budoff, Matthew J ; Cademartiri, Filippo ; Callister, Tracy Q ; Chang, Hyuk-Jae ; Chinnaiyan, Kavitha ; Chow, Benjamin J W ; Delago, Augustin ; Hadamitzky, Martin ; Hausleiter, Joerg ; Kaufmann, Philipp ; Maffei, Erica ; Raff, Gilbert ; Shaw, Leslee J ; Villines, Todd C ; Dunning, Allison ; Cury, Ricardo C ; Feuchtner, Gudrun ; Kim, Yong-Jin ; Leipsic, Jonathon ; Berman, Daniel S ; Min, James K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2291-b3fb5ef156889a3578ad62e8a44be4aed05961725759c07930cab453aa5aefc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Original</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otaki, Yuka</creatorcontrib><creatorcontrib>Gransar, Heidi</creatorcontrib><creatorcontrib>Cheng, Victor Y</creatorcontrib><creatorcontrib>Dey, Damini</creatorcontrib><creatorcontrib>Labounty, Troy</creatorcontrib><creatorcontrib>Lin, Fay Y</creatorcontrib><creatorcontrib>Achenbach, Stephan</creatorcontrib><creatorcontrib>Al-Mallah, Mouaz</creatorcontrib><creatorcontrib>Budoff, Matthew J</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><creatorcontrib>Callister, Tracy Q</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><creatorcontrib>Chinnaiyan, Kavitha</creatorcontrib><creatorcontrib>Chow, Benjamin J W</creatorcontrib><creatorcontrib>Delago, Augustin</creatorcontrib><creatorcontrib>Hadamitzky, Martin</creatorcontrib><creatorcontrib>Hausleiter, Joerg</creatorcontrib><creatorcontrib>Kaufmann, Philipp</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Raff, Gilbert</creatorcontrib><creatorcontrib>Shaw, Leslee J</creatorcontrib><creatorcontrib>Villines, Todd C</creatorcontrib><creatorcontrib>Dunning, Allison</creatorcontrib><creatorcontrib>Cury, Ricardo C</creatorcontrib><creatorcontrib>Feuchtner, Gudrun</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Berman, Daniel S</creatorcontrib><creatorcontrib>Min, James K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otaki, Yuka</au><au>Gransar, Heidi</au><au>Cheng, Victor Y</au><au>Dey, Damini</au><au>Labounty, Troy</au><au>Lin, Fay Y</au><au>Achenbach, Stephan</au><au>Al-Mallah, Mouaz</au><au>Budoff, Matthew J</au><au>Cademartiri, Filippo</au><au>Callister, Tracy Q</au><au>Chang, Hyuk-Jae</au><au>Chinnaiyan, Kavitha</au><au>Chow, Benjamin J W</au><au>Delago, Augustin</au><au>Hadamitzky, Martin</au><au>Hausleiter, Joerg</au><au>Kaufmann, Philipp</au><au>Maffei, Erica</au><au>Raff, Gilbert</au><au>Shaw, Leslee J</au><au>Villines, Todd C</au><au>Dunning, Allison</au><au>Cury, Ricardo C</au><au>Feuchtner, Gudrun</au><au>Kim, Yong-Jin</au><au>Leipsic, Jonathon</au><au>Berman, Daniel S</au><au>Min, James K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><date>2015-05</date><risdate>2015</risdate><volume>16</volume><issue>5</issue><spage>490</spage><epage>499</epage><pages>490-499</pages><issn>2047-2404</issn><eissn>2047-2412</eissn><abstract><![CDATA[Prior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry of consecutive young individuals undergoing coronary computerized tomographic angiography (CCTA).
Of 27 125 patients undergoing CCTA, 1635 young (<45 years) individuals without known coronary artery disease (CAD) or coronary anomalies were identified. Coronary plaque was assessed for any CAD, obstructive CAD (≥50% stenosis), and presence of calcified plaque (CP) and non-calcified plaque (NCP). Among 1635 subjects (70% men, age 38 ± 6 years), any CAD, obstructive CAD, CP, and NCP were observed in 19, 4, 5, and 8%, respectively. Compared with women, men demonstrated higher rates of any CAD (21 vs. 12%, P < 0.001), CP (6 vs. 3%, P = 0.01), and NCP (9 vs. 5%, P = 0.008), although no difference was observed for rates of obstructive CAD (5 vs. 4%, P = 0.46). Any CAD, obstructive CAD, and NCP were higher for young individuals with diabetes, hypertension, dyslipidaemia, current smoking, or family history of CAD; while only diabetes and dyslipidaemia were associated with CP. Increasing cardiovascular RFs was associated with a greater prevalence and extent and severity of CAD, with individuals with 0, 1, 2, ≥3 RFs manifesting a dose-response increase in any CAD (P < 0.001, for trend), obstructive CAD (P < 0.001, for trend), NCP (P < 0.001, for trend), and CP (P < 0.001, for trend). In multivariable analysis adjusting for sex and cardiovascular RFs, male sex was the strongest predictor for any CAD (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.43-2.66, P < 0.001), CP (OR = 1.46, 95% CI = 1.08-1.98, P = 0.01), and NCP (OR = 1.33, 95% CI = 1.06-1.67, P = 0.01); family history of CAD was the strongest predictor for obstructive CAD (OR = 2.71, 95% CI = 1.65-4.45, P < 0.001).
Any and obstructive CAD is present in 1 in 5 and 1 in 20 young individuals, respectively, with family history associated with the greatest risk of obstructive CAD.]]></abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25539786</pmid><doi>10.1093/ehjci/jeu281</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal cardiovascular imaging, 2015-05, Vol.16 (5), p.490-499 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Female Genetic Predisposition to Disease Humans Male Original Prevalence Prospective Studies Registries Risk Factors Severity of Illness Index Sex Factors Tomography, X-Ray Computed |
| title | Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry |
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