Dietary Restriction and Aging: A Unifying Perspective
Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of...
Gespeichert in:
| Veröffentlicht in: | Cell metabolism 2011-08, Vol.14 (2), p.154-160 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 160 |
|---|---|
| container_issue | 2 |
| container_start_page | 154 |
| container_title | Cell metabolism |
| container_volume | 14 |
| creator | Piper, Matthew D.W. Partridge, Linda Raubenheimer, David Simpson, Stephen J. |
| description | Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of nutrition, called the geometric framework, can better describe the responses of life span and other traits, including metabolism, and can reconcile these apparent contradictions. We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits. |
| doi_str_mv | 10.1016/j.cmet.2011.06.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4445606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550413111002646</els_id><sourcerecordid>880715543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c520t-3f2b3e04f086abc739ca5b5b775db08e8f9c3411e8e9427db7e33aa5cb85ddf53</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWqt_wIPszdOuk6_drIhQ6icIiug5ZLOzNaXdrcm24L83pVr04ikDeeadmYeQEwoZBZqfTzM7xz5jQGkGeQaU75ABLTlLC8FgN9ZSQioopwfkMIQpAM95yffJAaMKOFP5gMhrh73xn8kLht4727uuTUxbJ6OJaycXySh5a13zGevkGX1YYCRWeET2GjMLePz9Dsnb7c3r-D59fLp7GI8eUysZ9ClvWMURRAMqN5UteGmNrGRVFLKuQKFqSssFpaiwFKyoqwI5N0baSsm6biQfkqtN7mJZzbG22PbezPTCu3ncWXfG6b8_rXvXk26lhRAyhzwGnH0H-O5jGU_UcxcszmamxW4ZtFJQREuCR5JtSOu7EDw22ykU9Fq3nuq1br3WrSHXUXdsOv2937blx28ELjcARksrh14H67C1WDsfVeq6c__lfwFxQpHh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>880715543</pqid></control><display><type>article</type><title>Dietary Restriction and Aging: A Unifying Perspective</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Piper, Matthew D.W. ; Partridge, Linda ; Raubenheimer, David ; Simpson, Stephen J.</creator><creatorcontrib>Piper, Matthew D.W. ; Partridge, Linda ; Raubenheimer, David ; Simpson, Stephen J.</creatorcontrib><description>Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of nutrition, called the geometric framework, can better describe the responses of life span and other traits, including metabolism, and can reconcile these apparent contradictions. We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2011.06.013</identifier><identifier>PMID: 21803286</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - physiology ; Animals ; Diet ; Humans ; Life Expectancy ; Nutritional Requirements ; Signal Transduction - genetics</subject><ispartof>Cell metabolism, 2011-08, Vol.14 (2), p.154-160</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-3f2b3e04f086abc739ca5b5b775db08e8f9c3411e8e9427db7e33aa5cb85ddf53</citedby><cites>FETCH-LOGICAL-c520t-3f2b3e04f086abc739ca5b5b775db08e8f9c3411e8e9427db7e33aa5cb85ddf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550413111002646$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21803286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piper, Matthew D.W.</creatorcontrib><creatorcontrib>Partridge, Linda</creatorcontrib><creatorcontrib>Raubenheimer, David</creatorcontrib><creatorcontrib>Simpson, Stephen J.</creatorcontrib><title>Dietary Restriction and Aging: A Unifying Perspective</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of nutrition, called the geometric framework, can better describe the responses of life span and other traits, including metabolism, and can reconcile these apparent contradictions. We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Diet</subject><subject>Humans</subject><subject>Life Expectancy</subject><subject>Nutritional Requirements</subject><subject>Signal Transduction - genetics</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqt_wIPszdOuk6_drIhQ6icIiug5ZLOzNaXdrcm24L83pVr04ikDeeadmYeQEwoZBZqfTzM7xz5jQGkGeQaU75ABLTlLC8FgN9ZSQioopwfkMIQpAM95yffJAaMKOFP5gMhrh73xn8kLht4727uuTUxbJ6OJaycXySh5a13zGevkGX1YYCRWeET2GjMLePz9Dsnb7c3r-D59fLp7GI8eUysZ9ClvWMURRAMqN5UteGmNrGRVFLKuQKFqSssFpaiwFKyoqwI5N0baSsm6biQfkqtN7mJZzbG22PbezPTCu3ncWXfG6b8_rXvXk26lhRAyhzwGnH0H-O5jGU_UcxcszmamxW4ZtFJQREuCR5JtSOu7EDw22ykU9Fq3nuq1br3WrSHXUXdsOv2937blx28ELjcARksrh14H67C1WDsfVeq6c__lfwFxQpHh</recordid><startdate>20110803</startdate><enddate>20110803</enddate><creator>Piper, Matthew D.W.</creator><creator>Partridge, Linda</creator><creator>Raubenheimer, David</creator><creator>Simpson, Stephen J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110803</creationdate><title>Dietary Restriction and Aging: A Unifying Perspective</title><author>Piper, Matthew D.W. ; Partridge, Linda ; Raubenheimer, David ; Simpson, Stephen J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-3f2b3e04f086abc739ca5b5b775db08e8f9c3411e8e9427db7e33aa5cb85ddf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Diet</topic><topic>Humans</topic><topic>Life Expectancy</topic><topic>Nutritional Requirements</topic><topic>Signal Transduction - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piper, Matthew D.W.</creatorcontrib><creatorcontrib>Partridge, Linda</creatorcontrib><creatorcontrib>Raubenheimer, David</creatorcontrib><creatorcontrib>Simpson, Stephen J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piper, Matthew D.W.</au><au>Partridge, Linda</au><au>Raubenheimer, David</au><au>Simpson, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Restriction and Aging: A Unifying Perspective</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2011-08-03</date><risdate>2011</risdate><volume>14</volume><issue>2</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of nutrition, called the geometric framework, can better describe the responses of life span and other traits, including metabolism, and can reconcile these apparent contradictions. We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21803286</pmid><doi>10.1016/j.cmet.2011.06.013</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-4131 |
| ispartof | Cell metabolism, 2011-08, Vol.14 (2), p.154-160 |
| issn | 1550-4131 1932-7420 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4445606 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging - physiology Animals Diet Humans Life Expectancy Nutritional Requirements Signal Transduction - genetics |
| title | Dietary Restriction and Aging: A Unifying Perspective |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T16%3A54%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20Restriction%20and%20Aging:%20A%20Unifying%20Perspective&rft.jtitle=Cell%20metabolism&rft.au=Piper,%20Matthew%C2%A0D.W.&rft.date=2011-08-03&rft.volume=14&rft.issue=2&rft.spage=154&rft.epage=160&rft.pages=154-160&rft.issn=1550-4131&rft.eissn=1932-7420&rft_id=info:doi/10.1016/j.cmet.2011.06.013&rft_dat=%3Cproquest_pubme%3E880715543%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=880715543&rft_id=info:pmid/21803286&rft_els_id=S1550413111002646&rfr_iscdi=true |