Evolution of multidisciplinary brain metastasis management: case study and literature review
Up to 40 percent of all cancer patients develop brain metastasis (BM) during the course of their disease. Despite advances in diagnosis and therapy, prognosis in patients with BM remains poor for many patients, but for some, survival can be of the order of several years in duration. Difficulty in pr...
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| Veröffentlicht in: | The Yale journal of biology & medicine 2015-06, Vol.88 (2), p.157-165 |
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| description | Up to 40 percent of all cancer patients develop brain metastasis (BM) during the course of their disease. Despite advances in diagnosis and therapy, prognosis in patients with BM remains poor for many patients, but for some, survival can be of the order of several years in duration. Difficulty in predicting long-term survivors has created controversy in contemporary management of BM. Minimizing medical and neurocognitive side effects (disease borne or iatrogenic) to enhance functional independence and improving overall quality of life in these individuals requires a coordinated approach of first-line and salvage surgical, chemotherapeutic (cytotoxic, targeted, or immune based), and radiation (whole brain radiotherapy or stereotactic radiosurgery) modalities. This goal needs to be balanced against the more traditional targets of management such as symptom relief, reducing tumor burden, and local tumor control, thereby increasing progression-free survival. This case study and literature review demonstrates the role of various treatment modalities in the management of BM. |
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Despite advances in diagnosis and therapy, prognosis in patients with BM remains poor for many patients, but for some, survival can be of the order of several years in duration. Difficulty in predicting long-term survivors has created controversy in contemporary management of BM. Minimizing medical and neurocognitive side effects (disease borne or iatrogenic) to enhance functional independence and improving overall quality of life in these individuals requires a coordinated approach of first-line and salvage surgical, chemotherapeutic (cytotoxic, targeted, or immune based), and radiation (whole brain radiotherapy or stereotactic radiosurgery) modalities. This goal needs to be balanced against the more traditional targets of management such as symptom relief, reducing tumor burden, and local tumor control, thereby increasing progression-free survival. 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This work may not reflect the most current or accurate data available from NLM.</rights><rights>Copyright ©2015, Yale Journal of Biology and Medicine 2015 Yale Journal of Biology and Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445437/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445437/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26029014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colaco, Rovel</creatorcontrib><creatorcontrib>Martin, Pierre</creatorcontrib><creatorcontrib>Chiang, Veronica</creatorcontrib><title>Evolution of multidisciplinary brain metastasis management: case study and literature review</title><title>The Yale journal of biology & medicine</title><addtitle>Yale J Biol Med</addtitle><description>Up to 40 percent of all cancer patients develop brain metastasis (BM) during the course of their disease. 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| subjects | Asymptomatic Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - secondary Brain Neoplasms - therapy Cancer therapies Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Non-Small-Cell Lung - therapy Case Management Case studies Chemoradiotherapy - methods Chemotherapy Cognition Combined Modality Therapy Cytotoxicity Female Growth factors Histopathology Humans Hypotheses Literature reviews Lung cancer Magnetic resonance imaging Medical prognosis Metastases Metastasis Middle Aged Patient Care Team Patients Quality of life Radiation therapy Radiosurgery Radiosurgery - methods Review Surveillance Survival Treatment Outcome Tumors |
| title | Evolution of multidisciplinary brain metastasis management: case study and literature review |
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