Delta Frequency Optogenetic Stimulation of the Thalamic Nucleus Reuniens Is Sufficient to Produce Working Memory Deficits: Relevance to Schizophrenia

Abstract Background Low-frequency (delta/theta) oscillations in the thalamocortical system are elevated in schizophrenia during wakefulness and are also induced in the N -methyl-D-asparate receptor hypofunction rat model. To determine whether abnormal delta oscillations might produce functional defi...

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Veröffentlicht in:	Biological psychiatry (1969) 2015-06, Vol.77 (12), p.1098-1107
Hauptverfasser:	Duan, Aranda R, Varela, Carmen, Zhang, Yuchun, Shen, Yinghua, Xiong, Lealia, Wilson, Matthew A, Lisman, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Channelrhodopsin Delta Delta Rhythm - physiology Hippocampus - physiology Male Memory Disorders - etiology Memory Disorders - physiopathology Memory, Short-Term - physiology Midline Thalamic Nuclei - physiology Optogenetics Psychiatry Rats Rats, Long-Evans Reuniens Schizophrenia Schizophrenia - etiology Schizophrenia - physiopathology Schizophrenic Psychology Thalamus
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