Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
Abstract Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available medications. Thus, understanding the neural basis of these deficits is crucial for the development of new therapeutic interventions. The types of cognitive processes affected in schizophrenia are...
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| Veröffentlicht in: | Biological psychiatry (1969) 2015-06, Vol.77 (12), p.1031-1040 |
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| container_title | Biological psychiatry (1969) |
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| creator | Gonzalez-Burgos, Guillermo Cho, Raymond Y Lewis, David A |
| description | Abstract Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available medications. Thus, understanding the neural basis of these deficits is crucial for the development of new therapeutic interventions. The types of cognitive processes affected in schizophrenia are thought to depend on the precisely timed transmission of information in cortical regions via synchronous oscillations at gamma band frequency. Here, we review 1) data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia; 2) findings from basic neuroscience studies highlighting the features of parvalbumin-positive interneurons that are critical for gamma oscillation production; and 3) results from recent postmortem human brain studies providing additional molecular bases for parvalbumin-positive interneuron alterations in prefrontal cortical circuitry in schizophrenia. |
| doi_str_mv | 10.1016/j.biopsych.2015.03.010 |
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Thus, understanding the neural basis of these deficits is crucial for the development of new therapeutic interventions. The types of cognitive processes affected in schizophrenia are thought to depend on the precisely timed transmission of information in cortical regions via synchronous oscillations at gamma band frequency. Here, we review 1) data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia; 2) findings from basic neuroscience studies highlighting the features of parvalbumin-positive interneurons that are critical for gamma oscillation production; and 3) results from recent postmortem human brain studies providing additional molecular bases for parvalbumin-positive interneuron alterations in prefrontal cortical circuitry in schizophrenia.</description><subject>Animals</subject><subject>Brain Waves - physiology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cognition</subject><subject>Cortical Synchronization</subject><subject>GABA</subject><subject>GABAergic Neurons - physiology</subject><subject>Gamma oscillations</subject><subject>Gamma Rhythm - physiology</subject><subject>Humans</subject><subject>Inhibition</subject><subject>Models, Neurological</subject><subject>Nerve Net - physiopathology</subject><subject>Neural Inhibition</subject><subject>Parvalbumins</subject><subject>Prefrontal cortex</subject><subject>Psychiatry</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Working memory</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhL1Q5ckkYj2MnuVRUK76kqkUqPVuOM8t6m7UXO1m0_Hoc7bYCLvhij_zOO_Y8k2UXDEoGTL7blJ31u3gw6xKBiRJ4CQyeZQvW1LzACvB5tgAAWXBEfpa9inGTwhqRvczOUDSSc9EssvurYaSgR-tdzK3Llz6M1ughv6Hxpw8P-W00dhhOAu36_KsOez100zapb2gKp8Q7s7a__G4dyFn9Onux0kOkN6f9PLv_-OHb8nNxffvpy_LqujBS4liIXoqKYy26igwZ1pOmrhEdYt1xWNUSOMeVRFlVDTFEIM5YK7q2nc-C-Hl2efTdTd2WekNuDHpQu2C3OhyU11b9fePsWn33e1WlxWueDN6eDIL_MVEc1dZGQ-nDjvwUFZNtw1tA3iSpPEpN8DEGWj2VYaBmJmqjHpmomYkCrhKTlHjx5yOf0h4hJMH7o4BSq_aWgko9J2eot4HMqHpv_1_j8h8LM1g3g3ygA8WNn4JLIBRTERWou3ky5sFgAgCx4vw3oCW3Ow</recordid><startdate>20150615</startdate><enddate>20150615</enddate><creator>Gonzalez-Burgos, Guillermo</creator><creator>Cho, Raymond Y</creator><creator>Lewis, David A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150615</creationdate><title>Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia</title><author>Gonzalez-Burgos, Guillermo ; Cho, Raymond Y ; Lewis, David A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c662t-5d6543275b4ecec1deaeb85b227b30f760332f626448e1220e31195b99220e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Brain Waves - physiology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cognition</topic><topic>Cortical Synchronization</topic><topic>GABA</topic><topic>GABAergic Neurons - physiology</topic><topic>Gamma oscillations</topic><topic>Gamma Rhythm - physiology</topic><topic>Humans</topic><topic>Inhibition</topic><topic>Models, Neurological</topic><topic>Nerve Net - physiopathology</topic><topic>Neural Inhibition</topic><topic>Parvalbumins</topic><topic>Prefrontal cortex</topic><topic>Psychiatry</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez-Burgos, Guillermo</creatorcontrib><creatorcontrib>Cho, Raymond Y</creatorcontrib><creatorcontrib>Lewis, David A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez-Burgos, Guillermo</au><au>Cho, Raymond Y</au><au>Lewis, David A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2015-06-15</date><risdate>2015</risdate><volume>77</volume><issue>12</issue><spage>1031</spage><epage>1040</epage><pages>1031-1040</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><abstract>Abstract Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available medications. 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| ispartof | Biological psychiatry (1969), 2015-06, Vol.77 (12), p.1031-1040 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain Waves - physiology Cerebral Cortex - physiopathology Cognition Cortical Synchronization GABA GABAergic Neurons - physiology Gamma oscillations Gamma Rhythm - physiology Humans Inhibition Models, Neurological Nerve Net - physiopathology Neural Inhibition Parvalbumins Prefrontal cortex Psychiatry Schizophrenia - physiopathology Schizophrenic Psychology Working memory |
| title | Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia |
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