The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection
Central lymph node metastasis of papillary thyroid microcarcinoma (PTMC) is common; however, prophylactic central lymph node dissection (CLND) is still controversial because of the possible increased morbidity. The purpose of this study is to determine the clinical outcome of patients with cN0 PTMC...
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| Veröffentlicht in: | World journal of surgical oncology 2015-04, Vol.13 (1), p.138-138, Article 138 |
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| creator | Zhang, Liyang Liu, Ziwen Liu, Yuewu Gao, Weisheng Zheng, Chaoji |
| description | Central lymph node metastasis of papillary thyroid microcarcinoma (PTMC) is common; however, prophylactic central lymph node dissection (CLND) is still controversial because of the possible increased morbidity. The purpose of this study is to determine the clinical outcome of patients with cN0 PTMC by central neck dissection.
A retrospective cohort study was conducted on patients with PTMC without preoperative evidence of lymph node disease (cN0), and the outcomes were compared between patients undergoing total thyroidectomy (TT) alone (group A) and patients undergoing TT with CLND (group B).
In this study, 242 patients with cN0 PTMC were included. Group A had 108 patients and group B had 134 patients. During a follow-up of over 60 months, the long-term postoperative complications were equivalent between the two groups. In group B, the presence of involved central neck lymph nodes upstaged 16% of patients to stage III disease, which necessitated additional postoperative radioactive iodine treatment. More patients had recurrences in group A. The rate of reoperation in the central compartment was higher in group A than in group B (8.3% vs 2.2%, P |
| doi_str_mv | 10.1186/s12957-015-0553-2 |
| format | Article |
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A retrospective cohort study was conducted on patients with PTMC without preoperative evidence of lymph node disease (cN0), and the outcomes were compared between patients undergoing total thyroidectomy (TT) alone (group A) and patients undergoing TT with CLND (group B).
In this study, 242 patients with cN0 PTMC were included. Group A had 108 patients and group B had 134 patients. During a follow-up of over 60 months, the long-term postoperative complications were equivalent between the two groups. In group B, the presence of involved central neck lymph nodes upstaged 16% of patients to stage III disease, which necessitated additional postoperative radioactive iodine treatment. More patients had recurrences in group A. The rate of reoperation in the central compartment was higher in group A than in group B (8.3% vs 2.2%, P < 0.01).
Prophylactic CLND does not increase long-term postoperative complications and reduces the risk of recurrence in the central compartment.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/s12957-015-0553-2</identifier><identifier>PMID: 25889385</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Carcinoma, Papillary - prevention & control ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; Care and treatment ; Comparative analysis ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis - prevention & control ; Male ; Medical research ; Medicine, Experimental ; Metastasis ; Middle Aged ; Neck Dissection ; Neoplasm Recurrence, Local - prevention & control ; Patient outcomes ; Prognosis ; Prophylactic Surgical Procedures ; Radiotherapy ; Retrospective Studies ; Surgery ; Thyroid Neoplasms - prevention & control ; Thyroid Neoplasms - secondary ; Thyroid Neoplasms - surgery ; Thyroidectomy</subject><ispartof>World journal of surgical oncology, 2015-04, Vol.13 (1), p.138-138, Article 138</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Zhang et al.; licensee BioMed central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-bb7a7903896ae2bd60a57da0afd3328ab8376bf8aea80641ec9db7b1a61096b43</citedby><cites>FETCH-LOGICAL-c530t-bb7a7903896ae2bd60a57da0afd3328ab8376bf8aea80641ec9db7b1a61096b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443599/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443599/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25889385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Liyang</creatorcontrib><creatorcontrib>Liu, Ziwen</creatorcontrib><creatorcontrib>Liu, Yuewu</creatorcontrib><creatorcontrib>Gao, Weisheng</creatorcontrib><creatorcontrib>Zheng, Chaoji</creatorcontrib><title>The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>Central lymph node metastasis of papillary thyroid microcarcinoma (PTMC) is common; however, prophylactic central lymph node dissection (CLND) is still controversial because of the possible increased morbidity. The purpose of this study is to determine the clinical outcome of patients with cN0 PTMC by central neck dissection.
A retrospective cohort study was conducted on patients with PTMC without preoperative evidence of lymph node disease (cN0), and the outcomes were compared between patients undergoing total thyroidectomy (TT) alone (group A) and patients undergoing TT with CLND (group B).
In this study, 242 patients with cN0 PTMC were included. Group A had 108 patients and group B had 134 patients. During a follow-up of over 60 months, the long-term postoperative complications were equivalent between the two groups. In group B, the presence of involved central neck lymph nodes upstaged 16% of patients to stage III disease, which necessitated additional postoperative radioactive iodine treatment. More patients had recurrences in group A. The rate of reoperation in the central compartment was higher in group A than in group B (8.3% vs 2.2%, P < 0.01).
Prophylactic CLND does not increase long-term postoperative complications and reduces the risk of recurrence in the central compartment.</description><subject>Carcinoma, Papillary - prevention & control</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis - prevention & control</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neck Dissection</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Prophylactic Surgical Procedures</subject><subject>Radiotherapy</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Thyroid Neoplasms - prevention & control</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkl9rHCEUxaU0NGnaD9CXIhRKXybVcRz1pRBC_wRC-5I-y9VxdmxndKqzLfvt47DbsAvBB-X6O4fr9SD0hpIrSmX7MdNacVERyivCOavqZ-iCNkJUQlL1_Oh8jl7m_IuQmjHOXqDzmkupmOQXaHM_OGxHH7yFEc8pbkLMPuPY4xkW78KS8T-_DNh-J6Uy-3GEtMPLsEvRd3jyNkULyfoQJ8Bmh22RpGIVnP2NO5-zs4uP4RU662HM7vVhv0Q_v3y-v_lW3f34entzfVdZzshSGSNAKMKkasHVpmsJcNEBgb5jrJZgJBOt6SU4kKRtqLOqM8JQaClRrWnYJfq09523ZnLdoRs9Jz-VvnUEr09vgh_0Jv7VTdMwrlQx-HAwSPHP1uVFTz5bV54dXNxmTVvJuGCNZAV9t0c3MDrtQx-Lo11xfc0byglT9UpdPUGV1bkyvRhc70v9RPD-SDA4GJchx3G7jjGfgnQPlj_IObn-8ZmU6DUgeh8QXQKi14DoumjeHs_nUfE_EewBCpK3Vg</recordid><startdate>20150407</startdate><enddate>20150407</enddate><creator>Zhang, Liyang</creator><creator>Liu, Ziwen</creator><creator>Liu, Yuewu</creator><creator>Gao, Weisheng</creator><creator>Zheng, Chaoji</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150407</creationdate><title>The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection</title><author>Zhang, Liyang ; Liu, Ziwen ; Liu, Yuewu ; Gao, Weisheng ; Zheng, Chaoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-bb7a7903896ae2bd60a57da0afd3328ab8376bf8aea80641ec9db7b1a61096b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Carcinoma, Papillary - prevention & control</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis - prevention & control</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neck Dissection</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Prophylactic Surgical Procedures</topic><topic>Radiotherapy</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Thyroid Neoplasms - prevention & control</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Liyang</creatorcontrib><creatorcontrib>Liu, Ziwen</creatorcontrib><creatorcontrib>Liu, Yuewu</creatorcontrib><creatorcontrib>Gao, Weisheng</creatorcontrib><creatorcontrib>Zheng, Chaoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Liyang</au><au>Liu, Ziwen</au><au>Liu, Yuewu</au><au>Gao, Weisheng</au><au>Zheng, Chaoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2015-04-07</date><risdate>2015</risdate><volume>13</volume><issue>1</issue><spage>138</spage><epage>138</epage><pages>138-138</pages><artnum>138</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Central lymph node metastasis of papillary thyroid microcarcinoma (PTMC) is common; however, prophylactic central lymph node dissection (CLND) is still controversial because of the possible increased morbidity. The purpose of this study is to determine the clinical outcome of patients with cN0 PTMC by central neck dissection.
A retrospective cohort study was conducted on patients with PTMC without preoperative evidence of lymph node disease (cN0), and the outcomes were compared between patients undergoing total thyroidectomy (TT) alone (group A) and patients undergoing TT with CLND (group B).
In this study, 242 patients with cN0 PTMC were included. Group A had 108 patients and group B had 134 patients. During a follow-up of over 60 months, the long-term postoperative complications were equivalent between the two groups. In group B, the presence of involved central neck lymph nodes upstaged 16% of patients to stage III disease, which necessitated additional postoperative radioactive iodine treatment. More patients had recurrences in group A. The rate of reoperation in the central compartment was higher in group A than in group B (8.3% vs 2.2%, P < 0.01).
Prophylactic CLND does not increase long-term postoperative complications and reduces the risk of recurrence in the central compartment.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25889385</pmid><doi>10.1186/s12957-015-0553-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Carcinoma, Papillary - prevention & control Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery Care and treatment Comparative analysis Female Humans Lymph Node Excision Lymphatic Metastasis - prevention & control Male Medical research Medicine, Experimental Metastasis Middle Aged Neck Dissection Neoplasm Recurrence, Local - prevention & control Patient outcomes Prognosis Prophylactic Surgical Procedures Radiotherapy Retrospective Studies Surgery Thyroid Neoplasms - prevention & control Thyroid Neoplasms - secondary Thyroid Neoplasms - surgery Thyroidectomy |
| title | The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection |
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