The effect of regular aerobic exercise on reverse cholesterol transport a1 and apo lipoprotein a-i gene expression in inactive women

-Background: Atherosclerotic cardiovascular disease is currently a cause of mortality in some parts of the world. The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholest...

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Veröffentlicht in:Iranian red crescent medical journal 2015-04, Vol.17 (4), p.1-4
Hauptverfasser: Tofighi, Asghar, Rahmani, Fatimah, Qarakhanlou, Bahram Jamali, Babaei, Solmaz
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container_issue 4
container_start_page 1
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creator Tofighi, Asghar
Rahmani, Fatimah
Qarakhanlou, Bahram Jamali
Babaei, Solmaz
description -Background: Atherosclerotic cardiovascular disease is currently a cause of mortality in some parts of the world. The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholesterol, outside cells where they are limited to Apolipoprotein A1 (apoA1). Increased ABCA1 activity could inhibit atherosclerosis. Objectives: In the present study, the effect of aerobic exercise was investigated on gene expression and biochemical parameters. Patients and Methods: The participants included 36 inactive women, which were randomly assigned to control (CON) and experimental (EX) groups. The EX group performed 12 weeks of aerobic exercise and the CON group remained inactive. Fasting blood samples were collected 24 hours before the first session and 48 hours after completion of the course. The ABCA1 and APOA1 gene expressions were measured using semi-quantitative-RT-PCR. Data were analyzed by the SPSS software (version 18). Results: A significant increase in blood ABCA1 (EX group P < 0.002, t = - 9.876) and Apo A-I (EX group P < 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. Plasma high-density lipoprotein-cholesterol (HDL-C) concentration increased (P < 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (LDL-C) concentration decreased (P < 0.001, t = 4.27) in the EX group compared with the CON group. Conclusions: Aerobic exercises can increase ABCA1 and APO-A1 gene expression. Induction of these genes can effectively prevent cardiovascular disease.
doi_str_mv 10.5812/ircmj.17(4)2015.26321
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The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholesterol, outside cells where they are limited to Apolipoprotein A1 (apoA1). Increased ABCA1 activity could inhibit atherosclerosis. Objectives: In the present study, the effect of aerobic exercise was investigated on gene expression and biochemical parameters. Patients and Methods: The participants included 36 inactive women, which were randomly assigned to control (CON) and experimental (EX) groups. The EX group performed 12 weeks of aerobic exercise and the CON group remained inactive. Fasting blood samples were collected 24 hours before the first session and 48 hours after completion of the course. The ABCA1 and APOA1 gene expressions were measured using semi-quantitative-RT-PCR. Data were analyzed by the SPSS software (version 18). Results: A significant increase in blood ABCA1 (EX group P &lt; 0.002, t = - 9.876) and Apo A-I (EX group P &lt; 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. Plasma high-density lipoprotein-cholesterol (HDL-C) concentration increased (P &lt; 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (LDL-C) concentration decreased (P &lt; 0.001, t = 4.27) in the EX group compared with the CON group. Conclusions: Aerobic exercises can increase ABCA1 and APO-A1 gene expression. Induction of these genes can effectively prevent cardiovascular disease.</description><identifier>ISSN: 2074-1804</identifier><identifier>EISSN: 2074-1812</identifier><identifier>DOI: 10.5812/ircmj.17(4)2015.26321</identifier><identifier>PMID: 26023346</identifier><language>eng</language><publisher>Dubai, United Arab Emirates: Iranian Hospital</publisher><subject>Cardiovascular system ; Diseases ; Exercise therapy ; الأمراض</subject><ispartof>Iranian red crescent medical journal, 2015-04, Vol.17 (4), p.1-4</ispartof><rights>Copyright Iranian Hospital Dubai Apr 2015</rights><rights>Copyright © 2015, Iranian Red Crescent Medical Journal. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-ced6bf3aae65f0c0b66ab55d827a9a1f3c7c17d48d202046d334595a50917ef33</citedby><cites>FETCH-LOGICAL-c527t-ced6bf3aae65f0c0b66ab55d827a9a1f3c7c17d48d202046d334595a50917ef33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443300/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443300/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26023346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tofighi, Asghar</creatorcontrib><creatorcontrib>Rahmani, Fatimah</creatorcontrib><creatorcontrib>Qarakhanlou, Bahram Jamali</creatorcontrib><creatorcontrib>Babaei, Solmaz</creatorcontrib><title>The effect of regular aerobic exercise on reverse cholesterol transport a1 and apo lipoprotein a-i gene expression in inactive women</title><title>Iranian red crescent medical journal</title><addtitle>Iran Red Crescent Med J</addtitle><description>-Background: Atherosclerotic cardiovascular disease is currently a cause of mortality in some parts of the world. The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholesterol, outside cells where they are limited to Apolipoprotein A1 (apoA1). Increased ABCA1 activity could inhibit atherosclerosis. Objectives: In the present study, the effect of aerobic exercise was investigated on gene expression and biochemical parameters. Patients and Methods: The participants included 36 inactive women, which were randomly assigned to control (CON) and experimental (EX) groups. The EX group performed 12 weeks of aerobic exercise and the CON group remained inactive. Fasting blood samples were collected 24 hours before the first session and 48 hours after completion of the course. The ABCA1 and APOA1 gene expressions were measured using semi-quantitative-RT-PCR. Data were analyzed by the SPSS software (version 18). Results: A significant increase in blood ABCA1 (EX group P &lt; 0.002, t = - 9.876) and Apo A-I (EX group P &lt; 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. Plasma high-density lipoprotein-cholesterol (HDL-C) concentration increased (P &lt; 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (LDL-C) concentration decreased (P &lt; 0.001, t = 4.27) in the EX group compared with the CON group. Conclusions: Aerobic exercises can increase ABCA1 and APO-A1 gene expression. 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The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholesterol, outside cells where they are limited to Apolipoprotein A1 (apoA1). Increased ABCA1 activity could inhibit atherosclerosis. Objectives: In the present study, the effect of aerobic exercise was investigated on gene expression and biochemical parameters. Patients and Methods: The participants included 36 inactive women, which were randomly assigned to control (CON) and experimental (EX) groups. The EX group performed 12 weeks of aerobic exercise and the CON group remained inactive. Fasting blood samples were collected 24 hours before the first session and 48 hours after completion of the course. The ABCA1 and APOA1 gene expressions were measured using semi-quantitative-RT-PCR. Data were analyzed by the SPSS software (version 18). Results: A significant increase in blood ABCA1 (EX group P &lt; 0.002, t = - 9.876) and Apo A-I (EX group P &lt; 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. Plasma high-density lipoprotein-cholesterol (HDL-C) concentration increased (P &lt; 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (LDL-C) concentration decreased (P &lt; 0.001, t = 4.27) in the EX group compared with the CON group. Conclusions: Aerobic exercises can increase ABCA1 and APO-A1 gene expression. Induction of these genes can effectively prevent cardiovascular disease.</abstract><cop>Dubai, United Arab Emirates</cop><pub>Iranian Hospital</pub><pmid>26023346</pmid><doi>10.5812/ircmj.17(4)2015.26321</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects Cardiovascular system
Diseases
Exercise therapy
الأمراض
title The effect of regular aerobic exercise on reverse cholesterol transport a1 and apo lipoprotein a-i gene expression in inactive women
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