Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche

Stem cell self-renewal versus differentiation is regulated by the niche, which provides localized molecules that favor self-renewal. In the Drosophila melanogaster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a fly transforming growth factor β molecule and well-established long-rang...

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Veröffentlicht in:	The Journal of cell biology 2015-05, Vol.209 (4), p.595-608
Hauptverfasser:	Luo, Lichao, Wang, Huashan, Fan, Chao, Liu, Sen, Cai, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Proliferation Cellular biology Drosophila - cytology Drosophila - genetics Drosophila - metabolism Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Gene Expression Gene Expression Regulation Germ Cells - physiology Insects Ligands Molecules Ovary - cytology Ovary - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptor, Epidermal Growth Factor - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Invertebrate Peptide - metabolism Stem Cell Niche Stem cells Wnt Proteins - physiology Wnt Signaling Pathway
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