Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD

Obsessive compulsive disorder (OCD) has a complex etiology that encompasses both genetic and environmental factors. However, to date, despite the identification of several promising candidate genes and linkage regions, the genetic causes of OCD are largely unknown. The objective of this study was to...

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Veröffentlicht in:	Human genetics 2011-12, Vol.130 (6), p.795-805
Hauptverfasser:	Ross, Jessica, Badner, Judith, Garrido, Helena, Sheppard, Brooke, Chavira, Denise A., Grados, Marco, Woo, Jonathan M., Doo, Pamela, Umaña, Paula, Fournier, Eduardo, Murray, Sarah Shaw, Mathews, Carol A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Chromosome 1 chromosome 15 Chromosome Mapping - methods Chromosomes Chromosomes, Human, Pair 15 Classical genetics, quantitative genetics, hybrids Costa Rica - epidemiology Environmental factors Etiology Family Health Female Fundamental and applied biological sciences. Psychology Gene Function Gene loci Genes Genetic Linkage Genetic Predisposition to Disease Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study - methods Genomes Genomics Genotype Haplotypes Human Human Genetics Humans Investigations Linkage analysis Lod Score Male Metabolic Diseases Molecular Medicine Nucleotides Obsessive compulsive disorder Obsessive-Compulsive Disorder - epidemiology Obsessive-Compulsive Disorder - genetics Original Investigation Pedigree Polymorphism, Single Nucleotide Population genetics Psychiatry Ryanodine Receptor Calcium Release Channel - genetics Ryanodine receptors Sequence Analysis, DNA - methods Single-nucleotide polymorphism
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