p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation

Tumor suppressor p53 has been suggested to be a host restriction factor against HIV-1 replication, but the detailed molecular mechanism has remained elusive for decades. Here, we demonstrate that p53-mediated HIV-1 suppression is attributed to double-stranded RNA (dsRNA)-dependent protein kinase (PK...

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Veröffentlicht in:	Journal of virology 2015-04, Vol.89 (8), p.4262-4280
Hauptverfasser:	Yoon, Cheol-Hee, Kim, Sang-Yoon, Byeon, Se Eun, Jeong, Yideul, Lee, Jinjoo, Kim, Kwang Pyo, Park, Jinseu, Bae, Yong-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Blotting, Western CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell Line Cellular Response to Infection eIF-2 Kinase - metabolism Gene Knockdown Techniques HIV Infections - immunology HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunohistochemistry Immunoprecipitation Molecular Sequence Data Phosphorylation Sequence Analysis, DNA Tandem Mass Spectrometry Trans-Activators - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Two-Hybrid System Techniques Virus Replication - immunology
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