Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries

OBJECTIVE—Coronary artery disease (CAD), including myocardial infarction (MI), is the main cause of death in the world. Genome-wide association studies have identified dozens of single nucleotide polymorphisms (SNPs) associated with CAD/MI. One of the most robust CAD/MI genetic associations is with...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-06, Vol.35 (6), p.1472-1479
Hauptverfasser:	Beaudoin, Mélissa, Gupta, Rajat M, Won, Hong-Hee, Lo, Ken Sin, Do, Ron, Henderson, Christopher A, Lavoie-St-Amour, Claire, Langlois, Simon, Rivas, Daniel, Lehoux, Stephanie, Kathiresan, Sekar, Tardif, Jean-Claude, Musunuru, Kiran, Lettre, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Chromosomes, Human, Pair 6 - genetics Coronary Vessels - metabolism Endothelial Cells - metabolism Endothelium, Vascular - metabolism Genome-Wide Association Study Humans MEF2 Transcription Factors - metabolism Microfilament Proteins - metabolism Myocardial Infarction - genetics Myocardial Infarction - metabolism Polymorphism, Single Nucleotide Umbilicus - blood supply Veins
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