Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease

The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed thro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular psychiatry 2015-06, Vol.20 (6), p.677-684
Hauptverfasser: Kocerha, J, Dwivedi, Y, Brennand, K J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 684
container_issue 6
container_start_page 677
container_title Molecular psychiatry
container_volume 20
creator Kocerha, J
Dwivedi, Y
Brennand, K J
description The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.
doi_str_mv 10.1038/mp.2015.30
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4440836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A416717601</galeid><sourcerecordid>A416717601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhoMotl298QfIgDdSmTWZfM6NsNRPKBVEr0Mmc7KbMpOMyU6h_94MW2urooSQkPPkTd6Xg9AzgtcEU_V6nNYNJnxN8QN0TJgUNedSPSx7ytuaEcWO0EnOlxgvRf4YHTVcNYxieYzeXsRgY-_DtvpyscmVCX0VYE6xg5258jGZoRrB7kzwecyVD9WUr-3Om33ytup9BpPhCXrkzJDh6c26Qt_ev_t69rE-__zh09nmvLZc4n1NFcaiE4TTBmiLG8EkA9dh0TrnFCgsOWUtZp3pOtKUuTDGWecsK04IXaE3B91p7kboLYR9-Z-ekh9NutbReH2_EvxOb-OVZoxhRUUReHkjkOL3GfJejz5bGAYTIM5ZE7lE1CrZ_B8VrWwKX3RX6MVv6GWcUyhJ6IZSIogqiv-iiFDFa3HPf1FbM4D2wcVixC5P6w0jQhIp8BLE-i9UGT2M3sYAzpfzexdODxdsijkncLehEayXJtLjpJcm0hQX-PndmG_Rn11TgFcHIJdS2EK6Y-VPuR_SHsy9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1681907535</pqid></control><display><type>article</type><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kocerha, J ; Dwivedi, Y ; Brennand, K J</creator><creatorcontrib>Kocerha, J ; Dwivedi, Y ; Brennand, K J</creatorcontrib><description>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/mp.2015.30</identifier><identifier>PMID: 25824307</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/384/331 ; 631/378/2584/2585 ; 692/420 ; 692/699/476 ; Analysis ; Animals ; Antidepressants ; Behavior ; Behavioral Sciences ; Biological Psychology ; Bipolar disorder ; Care and treatment ; Central nervous system ; Cognition Disorders - etiology ; Diagnosis ; Disease ; Epigenetics ; Gene expression ; Genes ; Genomes ; Health aspects ; Human Genome Project ; Humans ; Medicine ; Medicine &amp; Public Health ; Mental disorders ; Mental Disorders - complications ; Mental Disorders - genetics ; MicroRNAs ; miRNA ; Nervous System Diseases - etiology ; Neurogenesis ; Neurosciences ; Non-coding RNA ; Pharmacotherapy ; Phenotypes ; Psychiatry ; Regulators ; review ; RNA ; RNA, Untranslated - genetics ; RNA, Untranslated - metabolism ; Schizophrenia ; Therapeutic targets</subject><ispartof>Molecular psychiatry, 2015-06, Vol.20 (6), p.677-684</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</citedby><cites>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/mp.2015.30$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/mp.2015.30$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25824307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocerha, J</creatorcontrib><creatorcontrib>Dwivedi, Y</creatorcontrib><creatorcontrib>Brennand, K J</creatorcontrib><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</description><subject>631/337/384/331</subject><subject>631/378/2584/2585</subject><subject>692/420</subject><subject>692/699/476</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Behavior</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Bipolar disorder</subject><subject>Care and treatment</subject><subject>Central nervous system</subject><subject>Cognition Disorders - etiology</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Human Genome Project</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mental disorders</subject><subject>Mental Disorders - complications</subject><subject>Mental Disorders - genetics</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Nervous System Diseases - etiology</subject><subject>Neurogenesis</subject><subject>Neurosciences</subject><subject>Non-coding RNA</subject><subject>Pharmacotherapy</subject><subject>Phenotypes</subject><subject>Psychiatry</subject><subject>Regulators</subject><subject>review</subject><subject>RNA</subject><subject>RNA, Untranslated - genetics</subject><subject>RNA, Untranslated - metabolism</subject><subject>Schizophrenia</subject><subject>Therapeutic targets</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl1rFDEUhoMotl298QfIgDdSmTWZfM6NsNRPKBVEr0Mmc7KbMpOMyU6h_94MW2urooSQkPPkTd6Xg9AzgtcEU_V6nNYNJnxN8QN0TJgUNedSPSx7ytuaEcWO0EnOlxgvRf4YHTVcNYxieYzeXsRgY-_DtvpyscmVCX0VYE6xg5258jGZoRrB7kzwecyVD9WUr-3Om33ytup9BpPhCXrkzJDh6c26Qt_ev_t69rE-__zh09nmvLZc4n1NFcaiE4TTBmiLG8EkA9dh0TrnFCgsOWUtZp3pOtKUuTDGWecsK04IXaE3B91p7kboLYR9-Z-ekh9NutbReH2_EvxOb-OVZoxhRUUReHkjkOL3GfJejz5bGAYTIM5ZE7lE1CrZ_B8VrWwKX3RX6MVv6GWcUyhJ6IZSIogqiv-iiFDFa3HPf1FbM4D2wcVixC5P6w0jQhIp8BLE-i9UGT2M3sYAzpfzexdODxdsijkncLehEayXJtLjpJcm0hQX-PndmG_Rn11TgFcHIJdS2EK6Y-VPuR_SHsy9</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Kocerha, J</creator><creator>Dwivedi, Y</creator><creator>Brennand, K J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><author>Kocerha, J ; Dwivedi, Y ; Brennand, K J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/337/384/331</topic><topic>631/378/2584/2585</topic><topic>692/420</topic><topic>692/699/476</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Behavior</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Bipolar disorder</topic><topic>Care and treatment</topic><topic>Central nervous system</topic><topic>Cognition Disorders - etiology</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Human Genome Project</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Mental disorders</topic><topic>Mental Disorders - complications</topic><topic>Mental Disorders - genetics</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Nervous System Diseases - etiology</topic><topic>Neurogenesis</topic><topic>Neurosciences</topic><topic>Non-coding RNA</topic><topic>Pharmacotherapy</topic><topic>Phenotypes</topic><topic>Psychiatry</topic><topic>Regulators</topic><topic>review</topic><topic>RNA</topic><topic>RNA, Untranslated - genetics</topic><topic>RNA, Untranslated - metabolism</topic><topic>Schizophrenia</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocerha, J</creatorcontrib><creatorcontrib>Dwivedi, Y</creatorcontrib><creatorcontrib>Brennand, K J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocerha, J</au><au>Dwivedi, Y</au><au>Brennand, K J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>20</volume><issue>6</issue><spage>677</spage><epage>684</epage><pages>677-684</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25824307</pmid><doi>10.1038/mp.2015.30</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-4184
ispartof Molecular psychiatry, 2015-06, Vol.20 (6), p.677-684
issn 1359-4184
1476-5578
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4440836
source MEDLINE; SpringerLink Journals
subjects 631/337/384/331
631/378/2584/2585
692/420
692/699/476
Analysis
Animals
Antidepressants
Behavior
Behavioral Sciences
Biological Psychology
Bipolar disorder
Care and treatment
Central nervous system
Cognition Disorders - etiology
Diagnosis
Disease
Epigenetics
Gene expression
Genes
Genomes
Health aspects
Human Genome Project
Humans
Medicine
Medicine & Public Health
Mental disorders
Mental Disorders - complications
Mental Disorders - genetics
MicroRNAs
miRNA
Nervous System Diseases - etiology
Neurogenesis
Neurosciences
Non-coding RNA
Pharmacotherapy
Phenotypes
Psychiatry
Regulators
review
RNA
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Schizophrenia
Therapeutic targets
title Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A26%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Noncoding%20RNAs%20and%20neurobehavioral%20mechanisms%20in%20psychiatric%20disease&rft.jtitle=Molecular%20psychiatry&rft.au=Kocerha,%20J&rft.date=2015-06-01&rft.volume=20&rft.issue=6&rft.spage=677&rft.epage=684&rft.pages=677-684&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/mp.2015.30&rft_dat=%3Cgale_pubme%3EA416717601%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1681907535&rft_id=info:pmid/25824307&rft_galeid=A416717601&rfr_iscdi=true