Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed thro...
Gespeichert in:
Veröffentlicht in: | Molecular psychiatry 2015-06, Vol.20 (6), p.677-684 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 684 |
---|---|
container_issue | 6 |
container_start_page | 677 |
container_title | Molecular psychiatry |
container_volume | 20 |
creator | Kocerha, J Dwivedi, Y Brennand, K J |
description | The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes. |
doi_str_mv | 10.1038/mp.2015.30 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4440836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A416717601</galeid><sourcerecordid>A416717601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhoMotl298QfIgDdSmTWZfM6NsNRPKBVEr0Mmc7KbMpOMyU6h_94MW2urooSQkPPkTd6Xg9AzgtcEU_V6nNYNJnxN8QN0TJgUNedSPSx7ytuaEcWO0EnOlxgvRf4YHTVcNYxieYzeXsRgY-_DtvpyscmVCX0VYE6xg5258jGZoRrB7kzwecyVD9WUr-3Om33ytup9BpPhCXrkzJDh6c26Qt_ev_t69rE-__zh09nmvLZc4n1NFcaiE4TTBmiLG8EkA9dh0TrnFCgsOWUtZp3pOtKUuTDGWecsK04IXaE3B91p7kboLYR9-Z-ekh9NutbReH2_EvxOb-OVZoxhRUUReHkjkOL3GfJejz5bGAYTIM5ZE7lE1CrZ_B8VrWwKX3RX6MVv6GWcUyhJ6IZSIogqiv-iiFDFa3HPf1FbM4D2wcVixC5P6w0jQhIp8BLE-i9UGT2M3sYAzpfzexdODxdsijkncLehEayXJtLjpJcm0hQX-PndmG_Rn11TgFcHIJdS2EK6Y-VPuR_SHsy9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1681907535</pqid></control><display><type>article</type><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kocerha, J ; Dwivedi, Y ; Brennand, K J</creator><creatorcontrib>Kocerha, J ; Dwivedi, Y ; Brennand, K J</creatorcontrib><description>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/mp.2015.30</identifier><identifier>PMID: 25824307</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/384/331 ; 631/378/2584/2585 ; 692/420 ; 692/699/476 ; Analysis ; Animals ; Antidepressants ; Behavior ; Behavioral Sciences ; Biological Psychology ; Bipolar disorder ; Care and treatment ; Central nervous system ; Cognition Disorders - etiology ; Diagnosis ; Disease ; Epigenetics ; Gene expression ; Genes ; Genomes ; Health aspects ; Human Genome Project ; Humans ; Medicine ; Medicine & Public Health ; Mental disorders ; Mental Disorders - complications ; Mental Disorders - genetics ; MicroRNAs ; miRNA ; Nervous System Diseases - etiology ; Neurogenesis ; Neurosciences ; Non-coding RNA ; Pharmacotherapy ; Phenotypes ; Psychiatry ; Regulators ; review ; RNA ; RNA, Untranslated - genetics ; RNA, Untranslated - metabolism ; Schizophrenia ; Therapeutic targets</subject><ispartof>Molecular psychiatry, 2015-06, Vol.20 (6), p.677-684</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</citedby><cites>FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/mp.2015.30$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/mp.2015.30$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25824307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocerha, J</creatorcontrib><creatorcontrib>Dwivedi, Y</creatorcontrib><creatorcontrib>Brennand, K J</creatorcontrib><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</description><subject>631/337/384/331</subject><subject>631/378/2584/2585</subject><subject>692/420</subject><subject>692/699/476</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Behavior</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Bipolar disorder</subject><subject>Care and treatment</subject><subject>Central nervous system</subject><subject>Cognition Disorders - etiology</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Human Genome Project</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Mental Disorders - complications</subject><subject>Mental Disorders - genetics</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Nervous System Diseases - etiology</subject><subject>Neurogenesis</subject><subject>Neurosciences</subject><subject>Non-coding RNA</subject><subject>Pharmacotherapy</subject><subject>Phenotypes</subject><subject>Psychiatry</subject><subject>Regulators</subject><subject>review</subject><subject>RNA</subject><subject>RNA, Untranslated - genetics</subject><subject>RNA, Untranslated - metabolism</subject><subject>Schizophrenia</subject><subject>Therapeutic targets</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl1rFDEUhoMotl298QfIgDdSmTWZfM6NsNRPKBVEr0Mmc7KbMpOMyU6h_94MW2urooSQkPPkTd6Xg9AzgtcEU_V6nNYNJnxN8QN0TJgUNedSPSx7ytuaEcWO0EnOlxgvRf4YHTVcNYxieYzeXsRgY-_DtvpyscmVCX0VYE6xg5258jGZoRrB7kzwecyVD9WUr-3Om33ytup9BpPhCXrkzJDh6c26Qt_ev_t69rE-__zh09nmvLZc4n1NFcaiE4TTBmiLG8EkA9dh0TrnFCgsOWUtZp3pOtKUuTDGWecsK04IXaE3B91p7kboLYR9-Z-ekh9NutbReH2_EvxOb-OVZoxhRUUReHkjkOL3GfJejz5bGAYTIM5ZE7lE1CrZ_B8VrWwKX3RX6MVv6GWcUyhJ6IZSIogqiv-iiFDFa3HPf1FbM4D2wcVixC5P6w0jQhIp8BLE-i9UGT2M3sYAzpfzexdODxdsijkncLehEayXJtLjpJcm0hQX-PndmG_Rn11TgFcHIJdS2EK6Y-VPuR_SHsy9</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Kocerha, J</creator><creator>Dwivedi, Y</creator><creator>Brennand, K J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</title><author>Kocerha, J ; Dwivedi, Y ; Brennand, K J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-38006b61532e39026474efb069fff8e807534904babb12bb19026afcffc435913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/337/384/331</topic><topic>631/378/2584/2585</topic><topic>692/420</topic><topic>692/699/476</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Behavior</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Bipolar disorder</topic><topic>Care and treatment</topic><topic>Central nervous system</topic><topic>Cognition Disorders - etiology</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Human Genome Project</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Mental Disorders - complications</topic><topic>Mental Disorders - genetics</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Nervous System Diseases - etiology</topic><topic>Neurogenesis</topic><topic>Neurosciences</topic><topic>Non-coding RNA</topic><topic>Pharmacotherapy</topic><topic>Phenotypes</topic><topic>Psychiatry</topic><topic>Regulators</topic><topic>review</topic><topic>RNA</topic><topic>RNA, Untranslated - genetics</topic><topic>RNA, Untranslated - metabolism</topic><topic>Schizophrenia</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocerha, J</creatorcontrib><creatorcontrib>Dwivedi, Y</creatorcontrib><creatorcontrib>Brennand, K J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocerha, J</au><au>Dwivedi, Y</au><au>Brennand, K J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>20</volume><issue>6</issue><spage>677</spage><epage>684</epage><pages>677-684</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25824307</pmid><doi>10.1038/mp.2015.30</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1359-4184 |
ispartof | Molecular psychiatry, 2015-06, Vol.20 (6), p.677-684 |
issn | 1359-4184 1476-5578 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4440836 |
source | MEDLINE; SpringerLink Journals |
subjects | 631/337/384/331 631/378/2584/2585 692/420 692/699/476 Analysis Animals Antidepressants Behavior Behavioral Sciences Biological Psychology Bipolar disorder Care and treatment Central nervous system Cognition Disorders - etiology Diagnosis Disease Epigenetics Gene expression Genes Genomes Health aspects Human Genome Project Humans Medicine Medicine & Public Health Mental disorders Mental Disorders - complications Mental Disorders - genetics MicroRNAs miRNA Nervous System Diseases - etiology Neurogenesis Neurosciences Non-coding RNA Pharmacotherapy Phenotypes Psychiatry Regulators review RNA RNA, Untranslated - genetics RNA, Untranslated - metabolism Schizophrenia Therapeutic targets |
title | Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A26%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Noncoding%20RNAs%20and%20neurobehavioral%20mechanisms%20in%20psychiatric%20disease&rft.jtitle=Molecular%20psychiatry&rft.au=Kocerha,%20J&rft.date=2015-06-01&rft.volume=20&rft.issue=6&rft.spage=677&rft.epage=684&rft.pages=677-684&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/mp.2015.30&rft_dat=%3Cgale_pubme%3EA416717601%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1681907535&rft_id=info:pmid/25824307&rft_galeid=A416717601&rfr_iscdi=true |