Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis

Alzheimer's disease (AD) is characterized by severe neuronal loss in several brain regions important for learning and memory. Of the structures affected by AD, the hippocampus is unique in continuing to produce new neurons throughout life. Mounting evidence indicates that hippocampal neurogenes...

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Veröffentlicht in:	The Journal of neuroscience 2007-06, Vol.27 (25), p.6771-6780
Hauptverfasser:	Verret, Laure, Jankowsky, Joanna L, Xu, Guilian M, Borchelt, David R, Rampon, Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloidosis - genetics Amyloidosis - metabolism Amyloidosis - pathology Animals Cell Survival - genetics Cellular Senescence - genetics Cognitive science Hippocampus - cytology Hippocampus - metabolism Hippocampus - pathology Humans Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Neurons - metabolism Neurons - pathology Neuroscience
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