Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray
Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identifi...
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| Veröffentlicht in: | Molecular medicine reports 2015-07, Vol.12 (1), p.800-818 |
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| description | Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer. |
| doi_str_mv | 10.3892/mmr.2015.3480 |
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In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2015.3480</identifier><identifier>PMID: 25778982</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Acids ; Anticarcinogenic Agents - administration & dosage ; Apoptosis ; Bexarotene ; Biological markers ; biomarker ; Biomarkers, Tumor - genetics ; Breast ; Breast - metabolism ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cell death ; Cell division ; Cell growth ; Cell Proliferation - genetics ; Cellular signal transduction ; Cloning ; E coli ; Epithelial Cells - drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Genes ; Growth factors ; Growth rate ; Health aspects ; Humans ; Kinases ; LG100268 ; LGD1069 ; Lymphoma ; MCF-7 Cells ; Microarray Analysis ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Nicotinic Acids - administration & dosage ; Physiological aspects ; Proteins ; Retinoid X receptors ; Retinoid X Receptors - agonists ; Retinoid X Receptors - genetics ; Retinoids ; rexinoid ; Ro25-7386 ; Studies ; Tetrahydronaphthalenes - administration & dosage ; Transcription factors ; Transduction ; Zinc</subject><ispartof>Molecular medicine reports, 2015-07, Vol.12 (1), p.800-818</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><rights>Copyright © 2015, Spandidos Publications 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-bb71bc9db3842785558a0051d916e4e3a5a01681332619524168cac8ded5094f3</citedby><cites>FETCH-LOGICAL-c580t-bb71bc9db3842785558a0051d916e4e3a5a01681332619524168cac8ded5094f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,5571,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25778982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEO, HYE-SOOK</creatorcontrib><creatorcontrib>WOO, JONG-KYU</creatorcontrib><creatorcontrib>SHIN, YONG CHEOL</creatorcontrib><creatorcontrib>KO, SEONG-GYU</creatorcontrib><title>Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.</description><subject>Acids</subject><subject>Anticarcinogenic Agents - administration & dosage</subject><subject>Apoptosis</subject><subject>Bexarotene</subject><subject>Biological markers</subject><subject>biomarker</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast</subject><subject>Breast - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell death</subject><subject>Cell division</subject><subject>Cell growth</subject><subject>Cell Proliferation - genetics</subject><subject>Cellular signal transduction</subject><subject>Cloning</subject><subject>E coli</subject><subject>Epithelial Cells - drug effects</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Growth factors</subject><subject>Growth rate</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>LG100268</subject><subject>LGD1069</subject><subject>Lymphoma</subject><subject>MCF-7 Cells</subject><subject>Microarray Analysis</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Nicotinic Acids - administration & dosage</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Retinoid X receptors</subject><subject>Retinoid X Receptors - agonists</subject><subject>Retinoid X Receptors - genetics</subject><subject>Retinoids</subject><subject>rexinoid</subject><subject>Ro25-7386</subject><subject>Studies</subject><subject>Tetrahydronaphthalenes - administration & dosage</subject><subject>Transcription factors</subject><subject>Transduction</subject><subject>Zinc</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkltrFDEYhgdRbK1eeisBL6zgrDkfboSl6lpYEESvQ2aS2abOJNtkRrq_oH-7GXZdrUgucnq-N7xf3qp6ieCCSIXfD0NaYIjYglAJH1WnSChUEwjp48MaKyVOqmc5X0PIGWbqaXWCmRBSSXxa3V1aF0bf-daMPgYQO9D4OJj006UMkttMvRmdBc2ubG59iN5mcL5efUSQq3dgvUIQYi6BCRZ8i5jVgkj-FvgArqbBBNAkZ_IIWtf3GUzZhw1Ydt1ucGPyt2DwbYomJbN7Xj3pTJ_di8N8Vv34_On7xZd6_XV1ebFc1y2TcKybRqCmVbYhkmIhGWPSQMiQVYg76ohhBiIuESGYI8UwLZvWtNI6y6CiHTmrPux1t1MzONsW88n0ept88bzT0Xj98Cb4K72JvzSlpd0MF4Hzg0CKN5PLox58nu2Z4OKUNeKCCEUQ4gV9_Q96HacUij2NFMGUK0LoH2pjeqd96GJ5t51F9ZJiwjjBatZa_Icqw7rSxBhc58v5g4J6X1A6nHNy3dEjgnpOji7J0XNy9Jycwr_6uzFH-ndUCvBmD-Rt-WxvYz4yRalGuIaohhJCcg-uj8hk</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>SEO, HYE-SOOK</creator><creator>WOO, JONG-KYU</creator><creator>SHIN, YONG CHEOL</creator><creator>KO, SEONG-GYU</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150701</creationdate><title>Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray</title><author>SEO, HYE-SOOK ; WOO, JONG-KYU ; SHIN, YONG CHEOL ; KO, SEONG-GYU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-bb71bc9db3842785558a0051d916e4e3a5a01681332619524168cac8ded5094f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Anticarcinogenic Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEO, HYE-SOOK</au><au>WOO, JONG-KYU</au><au>SHIN, YONG CHEOL</au><au>KO, SEONG-GYU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>12</volume><issue>1</issue><spage>800</spage><epage>818</epage><pages>800-818</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25778982</pmid><doi>10.3892/mmr.2015.3480</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2015-07, Vol.12 (1), p.800-818 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acids Anticarcinogenic Agents - administration & dosage Apoptosis Bexarotene Biological markers biomarker Biomarkers, Tumor - genetics Breast Breast - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell death Cell division Cell growth Cell Proliferation - genetics Cellular signal transduction Cloning E coli Epithelial Cells - drug effects Female Gene Expression Regulation, Neoplastic Genes Growth factors Growth rate Health aspects Humans Kinases LG100268 LGD1069 Lymphoma MCF-7 Cells Microarray Analysis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nicotinic Acids - administration & dosage Physiological aspects Proteins Retinoid X receptors Retinoid X Receptors - agonists Retinoid X Receptors - genetics Retinoids rexinoid Ro25-7386 Studies Tetrahydronaphthalenes - administration & dosage Transcription factors Transduction Zinc |
| title | Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray |
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