Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis
CCR7 orchestrates the development of TH1/TH17/Treg subsets, and their retention and lymphatic egress in experimental Crohnˈs disease. The regulation of T cell and DC retention and lymphatic egress within and from the intestine is critical for intestinal immunosurveillance; however, the cellular proc...
Gespeichert in:
| Veröffentlicht in: | Journal of leukocyte biology 2015-06, Vol.97 (6), p.1011-1022 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1022 |
|---|---|
| container_issue | 6 |
| container_start_page | 1011 |
| container_title | Journal of leukocyte biology |
| container_volume | 97 |
| creator | McNamee, Eóin N. Masterson, Joanne C. Veny, Marisol Collins, Colm B. Jedlicka, Paul Byrne, Fergus R. Ng, Gordon Y. Rivera‐Nieves, Jesús |
| description | CCR7 orchestrates the development of TH1/TH17/Treg subsets, and their retention and lymphatic egress in experimental Crohnˈs disease.
The regulation of T cell and DC retention and lymphatic egress within and from the intestine is critical for intestinal immunosurveillance; however, the cellular processes that orchestrate this balance during IBD remain poorly defined. With the use of a mouse model of TNF‐driven Crohnˈs‐like ileitis (TNFΔARE), we examined the role of CCR7 in the control of intestinal T cell and DC retention/egress during experimental CD. We observed that the frequency of CCR7‐expressing TH1/TH17 effector lymphocytes increased during active disease in TNFΔARE mice and that ΔARE/CCR7−/− mice developed exacerbated ileitis and multiorgan inflammation, with a marked polarization and ileal retention of TH1 effector CD4+ T cells. Furthermore, adoptive transfer of ΔARE/CCR7−/− effector CD4+ into lymphopenic hosts resulted in ileo‐colitis, whereas those transferred with ΔARE/CCR7+/+ CD4+ T cells developed ileitis. ΔARE/CCR7−/− mice had an acellular draining MLN, decreased CD103+ DC, and decreased expression of RALDH enzymes and of CD4+CD25+FoxP3+ Tregs. Lastly, a mAb against CCR7 exacerbated ileitis in TNFΔARE mice, phenocopying the effects of congenital CCR7 deficiency. Our data underscore a critical role for the lymphoid chemokine receptor CCR7 in orchestrating immune cell traffic and TH1 versus TH17 bias during chronic murine ileitis. |
| doi_str_mv | 10.1189/jlb.3HI0614-303R |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4438744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808686425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4561-2d676f4d56d9c2885253d9f6ee3e947d37b18966cda6bc0f23f081c6a8711c0c3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS1ERYeBPSvkJZt0fOP4JxskiIApGgmpGtaW4zgzbp1ksJOi7lh22ffqW_RJ8GimFay68P93ru7xQegdkDMAWS4ufX1Gl-eEQ5FRQi9eoBmUVGaUC_oSzYgoIGMFIafodYyXhBCac_IKneaMU8FKmCFfbW03XLne4mCN3Y1DwFV1IdJpM3k92ojHrcWuT7vR9drj9RIWaYjFOiG41l73xuJmCq7f4CoM2_7-Nj78ufPuyuJuf53k3rrRxTfopNU-2rfHdY5-fv2yrpbZ6se38-rTKjMF45DlDRe8LRrGm9LkUrKc0aZsubXUloVoqKiTec5No3ltSJvTlkgwXEsBYIihc_TxUHc31Z1tjO3HoL3aBdfpcKMG7dT_L73bqs1wrYqCSpGmOfpwLBCGX1NyrjoXjfXJqx2mqEASySUvUmPPolwywSgwSCg5oCYMMQbbPnUERO3zVClPdcxT7fNMkvf_OnkSPAaYAHYAfqc_vnm2oPq--gwEgP4F-jKuwA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685753151</pqid></control><display><type>article</type><title>Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>McNamee, Eóin N. ; Masterson, Joanne C. ; Veny, Marisol ; Collins, Colm B. ; Jedlicka, Paul ; Byrne, Fergus R. ; Ng, Gordon Y. ; Rivera‐Nieves, Jesús</creator><creatorcontrib>McNamee, Eóin N. ; Masterson, Joanne C. ; Veny, Marisol ; Collins, Colm B. ; Jedlicka, Paul ; Byrne, Fergus R. ; Ng, Gordon Y. ; Rivera‐Nieves, Jesús</creatorcontrib><description>CCR7 orchestrates the development of TH1/TH17/Treg subsets, and their retention and lymphatic egress in experimental Crohnˈs disease.
The regulation of T cell and DC retention and lymphatic egress within and from the intestine is critical for intestinal immunosurveillance; however, the cellular processes that orchestrate this balance during IBD remain poorly defined. With the use of a mouse model of TNF‐driven Crohnˈs‐like ileitis (TNFΔARE), we examined the role of CCR7 in the control of intestinal T cell and DC retention/egress during experimental CD. We observed that the frequency of CCR7‐expressing TH1/TH17 effector lymphocytes increased during active disease in TNFΔARE mice and that ΔARE/CCR7−/− mice developed exacerbated ileitis and multiorgan inflammation, with a marked polarization and ileal retention of TH1 effector CD4+ T cells. Furthermore, adoptive transfer of ΔARE/CCR7−/− effector CD4+ into lymphopenic hosts resulted in ileo‐colitis, whereas those transferred with ΔARE/CCR7+/+ CD4+ T cells developed ileitis. ΔARE/CCR7−/− mice had an acellular draining MLN, decreased CD103+ DC, and decreased expression of RALDH enzymes and of CD4+CD25+FoxP3+ Tregs. Lastly, a mAb against CCR7 exacerbated ileitis in TNFΔARE mice, phenocopying the effects of congenital CCR7 deficiency. Our data underscore a critical role for the lymphoid chemokine receptor CCR7 in orchestrating immune cell traffic and TH1 versus TH17 bias during chronic murine ileitis.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.3HI0614-303R</identifier><identifier>PMID: 25637591</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Adoptive Transfer ; Aldehyde Dehydrogenase - genetics ; Aldehyde Dehydrogenase - immunology ; Animals ; Antibodies, Monoclonal - pharmacology ; Antigens, CD - genetics ; Antigens, CD - immunology ; CD103+ dendritic cells ; Cell Movement - drug effects ; Crohn Disease - genetics ; Crohn Disease - immunology ; Crohn Disease - pathology ; Crohn's disease ; Dendritic Cells - drug effects ; Dendritic Cells - immunology ; Dendritic Cells - pathology ; Disease Models, Animal ; effector memory T cells ; Gene Expression Regulation ; Humans ; Ileitis - genetics ; Ileitis - immunology ; Ileitis - pathology ; Ileum - immunology ; Ileum - pathology ; inflammatory bowel disease ; Isoenzymes - genetics ; Isoenzymes - immunology ; lymphatics ; Mice ; Mice, Transgenic ; Receptors, CCR7 - antagonists & inhibitors ; Receptors, CCR7 - deficiency ; Receptors, CCR7 - genetics ; Receptors, CCR7 - immunology ; Signal Transduction ; Spotlight on Leading Edge Research ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - pathology ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th1 Cells - pathology ; Th1 Cells - transplantation ; Th17 Cells - drug effects ; Th17 Cells - immunology ; Th17 Cells - pathology ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - immunology</subject><ispartof>Journal of leukocyte biology, 2015-06, Vol.97 (6), p.1011-1022</ispartof><rights>2015 Society for Leukocyte Biology</rights><rights>Society for Leukocyte Biology.</rights><rights>Society for Leukocyte Biology 2015 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4561-2d676f4d56d9c2885253d9f6ee3e947d37b18966cda6bc0f23f081c6a8711c0c3</citedby><cites>FETCH-LOGICAL-c4561-2d676f4d56d9c2885253d9f6ee3e947d37b18966cda6bc0f23f081c6a8711c0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.3HI0614-303R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.3HI0614-303R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25637591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNamee, Eóin N.</creatorcontrib><creatorcontrib>Masterson, Joanne C.</creatorcontrib><creatorcontrib>Veny, Marisol</creatorcontrib><creatorcontrib>Collins, Colm B.</creatorcontrib><creatorcontrib>Jedlicka, Paul</creatorcontrib><creatorcontrib>Byrne, Fergus R.</creatorcontrib><creatorcontrib>Ng, Gordon Y.</creatorcontrib><creatorcontrib>Rivera‐Nieves, Jesús</creatorcontrib><title>Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>CCR7 orchestrates the development of TH1/TH17/Treg subsets, and their retention and lymphatic egress in experimental Crohnˈs disease.
The regulation of T cell and DC retention and lymphatic egress within and from the intestine is critical for intestinal immunosurveillance; however, the cellular processes that orchestrate this balance during IBD remain poorly defined. With the use of a mouse model of TNF‐driven Crohnˈs‐like ileitis (TNFΔARE), we examined the role of CCR7 in the control of intestinal T cell and DC retention/egress during experimental CD. We observed that the frequency of CCR7‐expressing TH1/TH17 effector lymphocytes increased during active disease in TNFΔARE mice and that ΔARE/CCR7−/− mice developed exacerbated ileitis and multiorgan inflammation, with a marked polarization and ileal retention of TH1 effector CD4+ T cells. Furthermore, adoptive transfer of ΔARE/CCR7−/− effector CD4+ into lymphopenic hosts resulted in ileo‐colitis, whereas those transferred with ΔARE/CCR7+/+ CD4+ T cells developed ileitis. ΔARE/CCR7−/− mice had an acellular draining MLN, decreased CD103+ DC, and decreased expression of RALDH enzymes and of CD4+CD25+FoxP3+ Tregs. Lastly, a mAb against CCR7 exacerbated ileitis in TNFΔARE mice, phenocopying the effects of congenital CCR7 deficiency. Our data underscore a critical role for the lymphoid chemokine receptor CCR7 in orchestrating immune cell traffic and TH1 versus TH17 bias during chronic murine ileitis.</description><subject>Adoptive Transfer</subject><subject>Aldehyde Dehydrogenase - genetics</subject><subject>Aldehyde Dehydrogenase - immunology</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>CD103+ dendritic cells</subject><subject>Cell Movement - drug effects</subject><subject>Crohn Disease - genetics</subject><subject>Crohn Disease - immunology</subject><subject>Crohn Disease - pathology</subject><subject>Crohn's disease</subject><subject>Dendritic Cells - drug effects</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - pathology</subject><subject>Disease Models, Animal</subject><subject>effector memory T cells</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Ileitis - genetics</subject><subject>Ileitis - immunology</subject><subject>Ileitis - pathology</subject><subject>Ileum - immunology</subject><subject>Ileum - pathology</subject><subject>inflammatory bowel disease</subject><subject>Isoenzymes - genetics</subject><subject>Isoenzymes - immunology</subject><subject>lymphatics</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Receptors, CCR7 - antagonists & inhibitors</subject><subject>Receptors, CCR7 - deficiency</subject><subject>Receptors, CCR7 - genetics</subject><subject>Receptors, CCR7 - immunology</subject><subject>Signal Transduction</subject><subject>Spotlight on Leading Edge Research</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - pathology</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th1 Cells - pathology</subject><subject>Th1 Cells - transplantation</subject><subject>Th17 Cells - drug effects</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - pathology</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1ERYeBPSvkJZt0fOP4JxskiIApGgmpGtaW4zgzbp1ksJOi7lh22ffqW_RJ8GimFay68P93ru7xQegdkDMAWS4ufX1Gl-eEQ5FRQi9eoBmUVGaUC_oSzYgoIGMFIafodYyXhBCac_IKneaMU8FKmCFfbW03XLne4mCN3Y1DwFV1IdJpM3k92ojHrcWuT7vR9drj9RIWaYjFOiG41l73xuJmCq7f4CoM2_7-Nj78ufPuyuJuf53k3rrRxTfopNU-2rfHdY5-fv2yrpbZ6se38-rTKjMF45DlDRe8LRrGm9LkUrKc0aZsubXUloVoqKiTec5No3ltSJvTlkgwXEsBYIihc_TxUHc31Z1tjO3HoL3aBdfpcKMG7dT_L73bqs1wrYqCSpGmOfpwLBCGX1NyrjoXjfXJqx2mqEASySUvUmPPolwywSgwSCg5oCYMMQbbPnUERO3zVClPdcxT7fNMkvf_OnkSPAaYAHYAfqc_vnm2oPq--gwEgP4F-jKuwA</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>McNamee, Eóin N.</creator><creator>Masterson, Joanne C.</creator><creator>Veny, Marisol</creator><creator>Collins, Colm B.</creator><creator>Jedlicka, Paul</creator><creator>Byrne, Fergus R.</creator><creator>Ng, Gordon Y.</creator><creator>Rivera‐Nieves, Jesús</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201506</creationdate><title>Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis</title><author>McNamee, Eóin N. ; Masterson, Joanne C. ; Veny, Marisol ; Collins, Colm B. ; Jedlicka, Paul ; Byrne, Fergus R. ; Ng, Gordon Y. ; Rivera‐Nieves, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4561-2d676f4d56d9c2885253d9f6ee3e947d37b18966cda6bc0f23f081c6a8711c0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adoptive Transfer</topic><topic>Aldehyde Dehydrogenase - genetics</topic><topic>Aldehyde Dehydrogenase - immunology</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>CD103+ dendritic cells</topic><topic>Cell Movement - drug effects</topic><topic>Crohn Disease - genetics</topic><topic>Crohn Disease - immunology</topic><topic>Crohn Disease - pathology</topic><topic>Crohn's disease</topic><topic>Dendritic Cells - drug effects</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - pathology</topic><topic>Disease Models, Animal</topic><topic>effector memory T cells</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Ileitis - genetics</topic><topic>Ileitis - immunology</topic><topic>Ileitis - pathology</topic><topic>Ileum - immunology</topic><topic>Ileum - pathology</topic><topic>inflammatory bowel disease</topic><topic>Isoenzymes - genetics</topic><topic>Isoenzymes - immunology</topic><topic>lymphatics</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Receptors, CCR7 - antagonists & inhibitors</topic><topic>Receptors, CCR7 - deficiency</topic><topic>Receptors, CCR7 - genetics</topic><topic>Receptors, CCR7 - immunology</topic><topic>Signal Transduction</topic><topic>Spotlight on Leading Edge Research</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - pathology</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th1 Cells - pathology</topic><topic>Th1 Cells - transplantation</topic><topic>Th17 Cells - drug effects</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - pathology</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNamee, Eóin N.</creatorcontrib><creatorcontrib>Masterson, Joanne C.</creatorcontrib><creatorcontrib>Veny, Marisol</creatorcontrib><creatorcontrib>Collins, Colm B.</creatorcontrib><creatorcontrib>Jedlicka, Paul</creatorcontrib><creatorcontrib>Byrne, Fergus R.</creatorcontrib><creatorcontrib>Ng, Gordon Y.</creatorcontrib><creatorcontrib>Rivera‐Nieves, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McNamee, Eóin N.</au><au>Masterson, Joanne C.</au><au>Veny, Marisol</au><au>Collins, Colm B.</au><au>Jedlicka, Paul</au><au>Byrne, Fergus R.</au><au>Ng, Gordon Y.</au><au>Rivera‐Nieves, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2015-06</date><risdate>2015</risdate><volume>97</volume><issue>6</issue><spage>1011</spage><epage>1022</epage><pages>1011-1022</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>CCR7 orchestrates the development of TH1/TH17/Treg subsets, and their retention and lymphatic egress in experimental Crohnˈs disease.
The regulation of T cell and DC retention and lymphatic egress within and from the intestine is critical for intestinal immunosurveillance; however, the cellular processes that orchestrate this balance during IBD remain poorly defined. With the use of a mouse model of TNF‐driven Crohnˈs‐like ileitis (TNFΔARE), we examined the role of CCR7 in the control of intestinal T cell and DC retention/egress during experimental CD. We observed that the frequency of CCR7‐expressing TH1/TH17 effector lymphocytes increased during active disease in TNFΔARE mice and that ΔARE/CCR7−/− mice developed exacerbated ileitis and multiorgan inflammation, with a marked polarization and ileal retention of TH1 effector CD4+ T cells. Furthermore, adoptive transfer of ΔARE/CCR7−/− effector CD4+ into lymphopenic hosts resulted in ileo‐colitis, whereas those transferred with ΔARE/CCR7+/+ CD4+ T cells developed ileitis. ΔARE/CCR7−/− mice had an acellular draining MLN, decreased CD103+ DC, and decreased expression of RALDH enzymes and of CD4+CD25+FoxP3+ Tregs. Lastly, a mAb against CCR7 exacerbated ileitis in TNFΔARE mice, phenocopying the effects of congenital CCR7 deficiency. Our data underscore a critical role for the lymphoid chemokine receptor CCR7 in orchestrating immune cell traffic and TH1 versus TH17 bias during chronic murine ileitis.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>25637591</pmid><doi>10.1189/jlb.3HI0614-303R</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 2015-06, Vol.97 (6), p.1011-1022 |
| issn | 0741-5400 1938-3673 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4438744 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adoptive Transfer Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - immunology Animals Antibodies, Monoclonal - pharmacology Antigens, CD - genetics Antigens, CD - immunology CD103+ dendritic cells Cell Movement - drug effects Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - pathology Crohn's disease Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - pathology Disease Models, Animal effector memory T cells Gene Expression Regulation Humans Ileitis - genetics Ileitis - immunology Ileitis - pathology Ileum - immunology Ileum - pathology inflammatory bowel disease Isoenzymes - genetics Isoenzymes - immunology lymphatics Mice Mice, Transgenic Receptors, CCR7 - antagonists & inhibitors Receptors, CCR7 - deficiency Receptors, CCR7 - genetics Receptors, CCR7 - immunology Signal Transduction Spotlight on Leading Edge Research T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - pathology Th1 Cells - transplantation Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - pathology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology |
| title | Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohnˈs‐like murine ileitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T13%3A16%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemokine%20receptor%20CCR7%20regulates%20the%20intestinal%20TH1/TH17/Treg%20balance%20during%20Crohn%CB%88s%E2%80%90like%20murine%20ileitis&rft.jtitle=Journal%20of%20leukocyte%20biology&rft.au=McNamee,%20E%C3%B3in%20N.&rft.date=2015-06&rft.volume=97&rft.issue=6&rft.spage=1011&rft.epage=1022&rft.pages=1011-1022&rft.issn=0741-5400&rft.eissn=1938-3673&rft_id=info:doi/10.1189/jlb.3HI0614-303R&rft_dat=%3Cproquest_pubme%3E1808686425%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1685753151&rft_id=info:pmid/25637591&rfr_iscdi=true |