Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

The critical period is a distinct time-window during the neonatal stage when animals display elevated sensitivity to certain environmental stimuli and particular experiences can have profound and long-lasting effects on behaviors. Increasing evidence suggests that disruption of neuronal activity dur...

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Veröffentlicht in:	Scientific reports 2015-05, Vol.5 (1), p.10252-10252, Article 10252
Hauptverfasser:	Yufune, Shinya, Satoh, Yasushi, Takamatsu, Isao, Ohta, Hiroyuki, Kobayashi, Yasushi, Takaenoki, Yumiko, Pagès, Gilles, Pouysségur, Jacques, Endo, Shogo, Kazama, Tomiei
Format:	Artikel
Sprache:	eng
Schlagworte:	45/41 631/378/1934 631/378/2571 631/378/3919 82/29 82/51 9/30 96/2 96/95 Age alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - analysis Aminoacetonitrile - analogs & derivatives Aminoacetonitrile - pharmacology Animals Apoptosis Apoptosis - drug effects Autism Autistic Disorder - metabolism Autistic Disorder - pathology Behavior, Animal - drug effects Blood-brain barrier Caspase 3 - metabolism Circuits Critical period Environmental effects Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Forebrain Hippocampus - metabolism Humanities and Social Sciences Immunohistochemistry Long-term potentiation Long-Term Potentiation - drug effects Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary N-Methylaspartate - analysis Neonates Neural networks Neurodevelopmental disorders Phenotype Phosphorylation Phosphorylation - drug effects Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Rodents Science
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