G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch

Nucleic acid based molecular device is a developing research field which attracts great interests in material for building machinelike nanodevices. G-quadruplex, as a new type of DNA secondary structures, can be harnessed to construct molecular device owing to its rich structural polymorphism. Herei...

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Veröffentlicht in:Scientific reports 2015-05, Vol.5 (1), p.10479-10479, Article 10479
Hauptverfasser: Guan, Ai-Jiao, Shen, Meng-Jie, Xiang, Jun-Feng, Zhang, En-Xuan, Li, Qian, Sun, Hong-Xia, Wang, Li-Xia, Xu, Guang-Zhi, Tang, Ya-Lin, Xu, Li-Jin, Gong, Han-Yuan
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Sprache:eng
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Zusammenfassung:Nucleic acid based molecular device is a developing research field which attracts great interests in material for building machinelike nanodevices. G-quadruplex, as a new type of DNA secondary structures, can be harnessed to construct molecular device owing to its rich structural polymorphism. Herein, we developed a switching system based on G-quadruplexes and methylazacalix[6]pyridine (MACP6). The induced circular dichroism (CD) signal of MACP6 was used to monitor the switch controlled by temperature or pH value. Furthermore, the CD titration, Job-plot, variable temperature CD and 1 H-NMR experiments not only confirmed the binding mode between MACP6 and G-quadruplex, but also explained the difference switching effect of MACP6 and various G-quadruplexes. The established strategy has the potential to be used as the chiral probe for specific G-quadruplex recognition.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep10479