Primary hepatic angiosarcoma: A report of two cases and literature review
Primary hepatic angiosarcoma (PHA) is a rare malignancy that carries a poor prognosis. Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and o...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-05, Vol.21 (19), p.6088-6096 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Zhu, Yi-Ping Chen, Yan-Min Matro, Erik Chen, Ren-Biao Jiang, Zhi-Nong Mou, Yi-Ping Hu, Hong-Jie Huang, Chao-Jie Wang, Guan-Yu |
| description | Primary hepatic angiosarcoma (PHA) is a rare malignancy that carries a poor prognosis. Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. Palliative chemotherapy is an option in advanced hepatic angiosarcoma. |
| doi_str_mv | 10.3748/wjg.v21.i19.6088 |
| format | Article |
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Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. Palliative chemotherapy is an option in advanced hepatic angiosarcoma.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v21.i19.6088</identifier><identifier>PMID: 26019478</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Biomarkers, Tumor - analysis ; Biopsy ; Case Report ; Chemoembolization, Therapeutic ; Chemotherapy, Adjuvant ; Fatal Outcome ; Female ; Hemangiosarcoma - chemistry ; Hemangiosarcoma - pathology ; Hemangiosarcoma - surgery ; Hepatectomy ; Humans ; Immunohistochemistry ; Liver Neoplasms - chemistry ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>World journal of gastroenterology : WJG, 2015-05, Vol.21 (19), p.6088-6096</ispartof><rights>The Author(s) 2015. 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Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. 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Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. Palliative chemotherapy is an option in advanced hepatic angiosarcoma.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>26019478</pmid><doi>10.3748/wjg.v21.i19.6088</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers, Tumor - analysis Biopsy Case Report Chemoembolization, Therapeutic Chemotherapy, Adjuvant Fatal Outcome Female Hemangiosarcoma - chemistry Hemangiosarcoma - pathology Hemangiosarcoma - surgery Hepatectomy Humans Immunohistochemistry Liver Neoplasms - chemistry Liver Neoplasms - pathology Liver Neoplasms - surgery Magnetic Resonance Imaging Male Middle Aged Time Factors Tomography, X-Ray Computed Treatment Outcome |
| title | Primary hepatic angiosarcoma: A report of two cases and literature review |
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