Liver involvement in pediatric celiac disease

Celiac disease (CD) is an intestinal inflammatory diseasethat manifests in genetically susceptible individualswhen exposed to dietary gluten. It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD...

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Veröffentlicht in:World journal of gastroenterology : WJG 2015-05, Vol.21 (19), p.5813-5822
Hauptverfasser: Anania, Caterina, De Luca, Ester, De Castro, Giovanna, Chiesa, Claudio, Pacifico, Lucia
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container_end_page 5822
container_issue 19
container_start_page 5813
container_title World journal of gastroenterology : WJG
container_volume 21
creator Anania, Caterina
De Luca, Ester
De Castro, Giovanna
Chiesa, Claudio
Pacifico, Lucia
description Celiac disease (CD) is an intestinal inflammatory diseasethat manifests in genetically susceptible individualswhen exposed to dietary gluten. It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD is remarkably varied, andthe disease can affect many extraintestinal organs andsystems, including the liver. The hepatic dysfunctionpresenting in CD ranges from asymptomatic liverenzyme elevations or nonspecific reactive hepatitis(cryptogenic liver disorders), to chronic liver disease.In this article, we review the clinical presentationsand possible mechanisms of CD-related liver injury toidentify strategies for the diagnosis and treatment ofthese disorders in childhood.
doi_str_mv 10.3748/wjg.v21.i19.5813
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source MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection
subjects Adolescent
Age Factors
Autoimmune Diseases - diagnosis
Autoimmune Diseases - etiology
Autoimmune Diseases - therapy
Autoimmunity
Celiac
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - diet therapy
Celiac Disease - immunology
Child
Child, Preschool
Cryptogenic
Diet, Gluten-Free
disease
End-stage
Fatty
Humans
hypertransaminasemia
Autoimmune
liver
Liver Diseases - diagnosis
Liver Diseases - etiology
Liver Diseases - immunology
Liver Diseases - therapy
Liver Function Tests
liverdisease
Minireviews
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - etiology
Non-alcoholic Fatty Liver Disease - therapy
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Treatment Outcome
title Liver involvement in pediatric celiac disease
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