Liver involvement in pediatric celiac disease
Celiac disease (CD) is an intestinal inflammatory diseasethat manifests in genetically susceptible individualswhen exposed to dietary gluten. It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD...
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Veröffentlicht in: | World journal of gastroenterology : WJG 2015-05, Vol.21 (19), p.5813-5822 |
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creator | Anania, Caterina De Luca, Ester De Castro, Giovanna Chiesa, Claudio Pacifico, Lucia |
description | Celiac disease (CD) is an intestinal inflammatory diseasethat manifests in genetically susceptible individualswhen exposed to dietary gluten. It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD is remarkably varied, andthe disease can affect many extraintestinal organs andsystems, including the liver. The hepatic dysfunctionpresenting in CD ranges from asymptomatic liverenzyme elevations or nonspecific reactive hepatitis(cryptogenic liver disorders), to chronic liver disease.In this article, we review the clinical presentationsand possible mechanisms of CD-related liver injury toidentify strategies for the diagnosis and treatment ofthese disorders in childhood. |
doi_str_mv | 10.3748/wjg.v21.i19.5813 |
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It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD is remarkably varied, andthe disease can affect many extraintestinal organs andsystems, including the liver. The hepatic dysfunctionpresenting in CD ranges from asymptomatic liverenzyme elevations or nonspecific reactive hepatitis(cryptogenic liver disorders), to chronic liver disease.In this article, we review the clinical presentationsand possible mechanisms of CD-related liver injury toidentify strategies for the diagnosis and treatment ofthese disorders in childhood.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v21.i19.5813</identifier><identifier>PMID: 26019445</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adolescent ; Age Factors ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - etiology ; Autoimmune Diseases - therapy ; Autoimmunity ; Celiac ; Celiac Disease - complications ; Celiac Disease - diagnosis ; Celiac Disease - diet therapy ; Celiac Disease - immunology ; Child ; Child, Preschool ; Cryptogenic ; Diet, Gluten-Free ; disease ; End-stage ; Fatty ; Humans ; hypertransaminasemia;Autoimmune ; liver ; Liver Diseases - diagnosis ; Liver Diseases - etiology ; Liver Diseases - immunology ; Liver Diseases - therapy ; Liver Function Tests ; liverdisease ; Minireviews ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - therapy ; Predictive Value of Tests ; Risk Factors ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>World journal of gastroenterology : WJG, 2015-05, Vol.21 (19), p.5813-5822</ispartof><rights>The Author(s) 2015. 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All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-93f4e3892e9f5bdeec71ddaae24d50e1396c0739684156089779ec63dbac15c43</citedby><cites>FETCH-LOGICAL-c423t-93f4e3892e9f5bdeec71ddaae24d50e1396c0739684156089779ec63dbac15c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438015/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438015/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26019445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anania, Caterina</creatorcontrib><creatorcontrib>De Luca, Ester</creatorcontrib><creatorcontrib>De Castro, Giovanna</creatorcontrib><creatorcontrib>Chiesa, Claudio</creatorcontrib><creatorcontrib>Pacifico, Lucia</creatorcontrib><title>Liver involvement in pediatric celiac disease</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>Celiac disease (CD) is an intestinal inflammatory diseasethat manifests in genetically susceptible individualswhen exposed to dietary gluten. It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD is remarkably varied, andthe disease can affect many extraintestinal organs andsystems, including the liver. The hepatic dysfunctionpresenting in CD ranges from asymptomatic liverenzyme elevations or nonspecific reactive hepatitis(cryptogenic liver disorders), to chronic liver disease.In this article, we review the clinical presentationsand possible mechanisms of CD-related liver injury toidentify strategies for the diagnosis and treatment ofthese disorders in childhood.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - etiology</subject><subject>Autoimmune Diseases - therapy</subject><subject>Autoimmunity</subject><subject>Celiac</subject><subject>Celiac Disease - complications</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - diet therapy</subject><subject>Celiac Disease - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cryptogenic</subject><subject>Diet, Gluten-Free</subject><subject>disease</subject><subject>End-stage</subject><subject>Fatty</subject><subject>Humans</subject><subject>hypertransaminasemia;Autoimmune</subject><subject>liver</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - immunology</subject><subject>Liver Diseases - therapy</subject><subject>Liver Function Tests</subject><subject>liverdisease</subject><subject>Minireviews</subject><subject>Non-alcoholic Fatty Liver Disease - diagnosis</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>Non-alcoholic Fatty Liver Disease - therapy</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLAzEQxoMotlbvnmTx5GXXvDe5CFJ8QcGLnkOand2m7KPdtCv-96a0Fr3MDMw338z8ELomOGM5V_dfyyobKMk80ZlQhJ2gMaVEp1RxfIrGBOM81YzmI3QRwhJjypig52hEJSaaczFG6cwP0Ce-Hbp6gAbaTayTFRTebnrvEge1ty4pfAAb4BKdlbYOcHXIE_T5_PQxfU1n7y9v08dZ6jhlm7iy5MCUpqBLMS8AXE6KwlqgvBAYCNPS4TxGxYmQWOk81-AkK-bWEeE4m6CHve9qO2-gcPGs3tZm1fvG9t-ms97877R-YapuMJwzhYmIBncHg75bbyFsTOND_KW2LXTbYIjUSkvOiIxSvJe6vguhh_K4hmCzo2wiZRMpm0jZ7CjHkZu_5x0HfrFGwe3Bc9G11dq31VEjpZBc0vj-D071hW8</recordid><startdate>20150521</startdate><enddate>20150521</enddate><creator>Anania, Caterina</creator><creator>De Luca, Ester</creator><creator>De Castro, Giovanna</creator><creator>Chiesa, Claudio</creator><creator>Pacifico, Lucia</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150521</creationdate><title>Liver involvement in pediatric celiac disease</title><author>Anania, Caterina ; 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It is a common chronicdisorder, with a prevalence of 1% in Europe and NorthAmerica. Although the disease primarily affects the gut,the clinical spectrum of CD is remarkably varied, andthe disease can affect many extraintestinal organs andsystems, including the liver. The hepatic dysfunctionpresenting in CD ranges from asymptomatic liverenzyme elevations or nonspecific reactive hepatitis(cryptogenic liver disorders), to chronic liver disease.In this article, we review the clinical presentationsand possible mechanisms of CD-related liver injury toidentify strategies for the diagnosis and treatment ofthese disorders in childhood.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>26019445</pmid><doi>10.3748/wjg.v21.i19.5813</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
subjects | Adolescent Age Factors Autoimmune Diseases - diagnosis Autoimmune Diseases - etiology Autoimmune Diseases - therapy Autoimmunity Celiac Celiac Disease - complications Celiac Disease - diagnosis Celiac Disease - diet therapy Celiac Disease - immunology Child Child, Preschool Cryptogenic Diet, Gluten-Free disease End-stage Fatty Humans hypertransaminasemia Autoimmune liver Liver Diseases - diagnosis Liver Diseases - etiology Liver Diseases - immunology Liver Diseases - therapy Liver Function Tests liverdisease Minireviews Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - therapy Predictive Value of Tests Risk Factors Severity of Illness Index Treatment Outcome |
title | Liver involvement in pediatric celiac disease |
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