Genetic variants in one‐carbon metabolism genes and breast cancer risk in European American and African American women

Folate‐mediated one‐carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate‐metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of Afri...

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Veröffentlicht in:	International journal of cancer 2015-08, Vol.137 (3), p.666-677
Hauptverfasser:	Gong, Zhihong, Yao, Song, Zirpoli, Gary, David Cheng, Ting‐Yuan, Roberts, Michelle, Khoury, Thaer, Ciupak, Gregory, Davis, Warren, Pawlish, Karen, Jandorf, Lina, Bovbjerg, Dana H., Bandera, Elisa V., Ambrosone, Christine B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African American Alleles Black or African American Black People - genetics Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - epidemiology Breast Neoplasms - genetics Cancer Carbon Case-Control Studies Deoxyribonucleic acid Diet DNA DNA methylation Europe - epidemiology European American Female Folic Acid - metabolism Gene Frequency Genealogy Genes Genetic Predisposition to Disease Genetic Variation Genotype Health risk assessment Humans Medical research Metabolism Middle Aged Multifactorial Inheritance Odds Ratio one‐carbon metabolism Polymorphism, Single Nucleotide polymorphisms Population Surveillance Receptors, Estrogen - genetics Risk Risk Factors United States - epidemiology Vitamin B
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