Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

Extracts from the rhizome of the turmeric plant are widely consumed as anti-inflammatory dietary supplements. Turmeric extract contains the three curcuminoids, curcumin (≈80% relative abundance), demethoxycurcumin (DMC; ≈15%), and bisdemethoxycurcumin (BDMC; ≈5%). A distinct feature of pure curcumin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical research in toxicology 2015-05, Vol.28 (5), p.989-996
Hauptverfasser:	Gordon, Odaine N, Luis, Paula B, Ashley, Rachel E, Osheroff, Neil, Schneider, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - chemistry Antigens, Neoplasm - metabolism Curcuma - chemistry Curcuma - metabolism Curcuma - toxicity Curcumin - analogs & derivatives Curcumin - chemistry Curcumin - metabolism Curcumin - toxicity Diarylheptanoids DNA Cleavage - drug effects DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Epoxy Compounds - chemistry Epoxy Compounds - metabolism Epoxy Compounds - toxicity Humans Oxidation-Reduction Plant Extracts - chemistry Plant Extracts - metabolism Plant Extracts - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!