Development of an on-animal separation-based sensor for monitoring drug metabolism in freely roaming sheep

The development of an on-animal separation-based sensor that can be employed for monitoring drug metabolism in a freely roaming sheep is described. The system consists of microdialysis sampling coupled to microchip electrophoresis with electrochemical detection (MD-ME-EC). Separations were accomplis...

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Veröffentlicht in:	Analyst (London) 2015-06, Vol.140 (11), p.3820-3829
Hauptverfasser:	Scott, David E, Willis, Sean D, Gabbert, Seth, Johnson, David, Naylor, Erik, Janle, Elsa M, Krichevsky, Janice E, Lunte, Craig E, Lunte, Susan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chips Devices Drugs Electrochemistry Electrodes Electrophoresis Electrophoresis, Microchip Equipment Design Male Metabolism Microdialysis Microtechnology - instrumentation Monitors Movement Nitroglycerin Pharmaceutical Preparations - isolation & purification Pharmaceutical Preparations - metabolism Rats Sheep
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