Endothelial microparticles: Sophisticated vesicles modulating vascular function
Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fu...
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| Veröffentlicht in: | Vascular medicine (London, England) England), 2013-08, Vol.18 (4), p.204-214 |
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| container_title | Vascular medicine (London, England) |
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| creator | Curtis, Anne M Edelberg, Jay Jonas, Rebecca Rogers, Wade T Moore, Jonni S Syed, Wajihuddin Mohler, Emile R |
| description | Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation. |
| doi_str_mv | 10.1177/1358863X13499773 |
| format | Article |
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The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. 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A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.</description><subject>Animals</subject><subject>Cell Communication</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cell-Derived Microparticles - pathology</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Humans</subject><subject>Signal Transduction</subject><subject>Vascular Diseases - metabolism</subject><subject>Vascular Diseases - pathology</subject><subject>Vascular Diseases - physiopathology</subject><subject>Vascular Diseases - therapy</subject><issn>1358-863X</issn><issn>1477-0377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1v1DAQxS0EoqVw54QiceES8NhOxuGAVFXlQ6rUAyBxsxxnvOsqiRc7WYn_Hi9bqlKJk8d-v3n2-DH2EvhbAMR3IButW_kDpOo6RPmInYJCrLlEfFzqItcH_YQ9y_mGc45tB0_ZiZC6E0rhKbu-nIe4bGkMdqym4FLc2bQEN1J-X32Nu23IZWcXGqo95T_n1RSHdbRLmDfV3mZX6lT5dXZLiPNz9sTbMdOL2_WMff94-e3ic311_enLxflV7Rqhl1pQ3wwoe6V9D6SFU23byxa8bTiCHkCC670A8rZzwiI5HBrfdoRcey6UPGMfjr67tZ9ocDQvyY5ml8Jk0y8TbTD_KnPYmk3cG6UkNq0uBm9uDVL8uVJezBSyo3G0M8U1G1ACUekGsKCvH6A3cU1zGe9AtRoObKH4kSp_mHMif_cY4OaQlnmYVml5dX-Iu4a_8RSgPgLZbujerf8z_A3KOZ8z</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Curtis, Anne M</creator><creator>Edelberg, Jay</creator><creator>Jonas, Rebecca</creator><creator>Rogers, Wade T</creator><creator>Moore, Jonni S</creator><creator>Syed, Wajihuddin</creator><creator>Mohler, Emile R</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Endothelial microparticles: Sophisticated vesicles modulating vascular function</title><author>Curtis, Anne M ; 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| issn | 1358-863X 1477-0377 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete; Alma/SFX Local Collection |
| subjects | Animals Cell Communication Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Humans Signal Transduction Vascular Diseases - metabolism Vascular Diseases - pathology Vascular Diseases - physiopathology Vascular Diseases - therapy |
| title | Endothelial microparticles: Sophisticated vesicles modulating vascular function |
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