Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

The clinical interest in farnesyltransferase inhibitors (FTIs) makes it important to understand how these compounds affect cellular processes involving farnesylated proteins. Mitotic abnormalities observed after treatment with FTIs have so far been attributed to defects in the farnesylation of the o...

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Veröffentlicht in:	Molecular biology of the cell 2015-05, Vol.26 (10), p.1845-1856
Hauptverfasser:	Holland, Andrew J, Reis, Rita M, Niessen, Sherry, Pereira, Cláudia, Andres, Douglas A, Spielmann, H Peter, Cleveland, Don W, Desai, Arshad, Gassmann, Reto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation - drug effects Dynactin Complex Dyneins - drug effects Enzyme Inhibitors - pharmacology Farnesyltranstransferase - antagonists & inhibitors Farnesyltranstransferase - metabolism Humans Kinetochores - drug effects Kinetochores - metabolism Microtubule-Associated Proteins - drug effects Mitosis - drug effects Protein Prenylation Xenopus
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