Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin
AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development． METHODS：An IUGR rat model was established by food restriction of pregnant female rat...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-07, Vol.11 (28), p.4419-4422 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Qiu, Xiao-Shan Huang, Ting-Ting Shen, Zhen-Yu Deng, Hui-Ying Ke, Zhi-Yong |
| description | AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development．
METHODS：An IUGR rat model was established by food restriction of pregnant female rats．Fifty-six neonatal IUGR rats and 24 neonatal normal rats were randomly divided into normal control group（Cgroup），IUGR model group （scgroup），low protein diet IUGR group（SL group），and high protein diet IUGR group（SH group）．Eight rats were killed per group at wk 0，4，and 12．Serum leptin，body weight（BW），body length（BL），intestinal weight（IW），intestinal length（IL），andintestinal disaccharidase（including lactase，maltase，and saccharase） were detected．
RESULTS：BW（4．50±0．41g），BL（5．96±0．40cm），IW（0．05±0．01g），and IL（15.9±2．8cm）in neonatal IUGR rats were much lower than those in Cgroup（6．01±0．55g，6．26±0．44cm，0．10±0．02g，21.8±2．7cm，P〈0．05），while intestinal lactase and maltase activities were higher than those in Cgroup．SH group showed the fastest catch up growth and their BW，BL，IW，and IL reached the Cgroup level at wk 4．SC group showed relatively slower catch up growth than SH group，and their BW，BL，IW did not reach the Cgroup level at wk 4．SL group did not show intestine and body catch up growth．Intestinal maltase [344±33μmol／（min·q）]and saccharase activities[138±32μmol／（min·g）]in SL group were both markedly lower than nose in C group [751±102，258±271μmol／（min·g），P〈0．05]．There were no significant difierences in lactase activities at wk 4 and disaccharidase activities at wk 12 among all groups（P〈0．05）．The leptin level in SL group（0．58±0．12ng／mL） was the highest in all groups，and much lower in SH group（0．21±0．03ng／mL） than that in any other IUGR groups at wk 4（P〈0．05）．Leptin was negatively related to BW （r=-0．556，P=0．001），IW（r=-0．692，P=0．001） and IL（r=-0．738，P=0．000）at wk 4，while no correlation was found at wk 12．
CONCLUSION：High protein diet is a reasonable early nutritional mode to IUGR rats in promoting intestine and body catch up growth． |
| doi_str_mv | 10.3748/wjg.v11.i28.4419 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4434673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>18012351</cqvip_id><wanfj_id>wjg200528023</wanfj_id><sourcerecordid>wjg200528023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-d4f0ea71c75d20460dcc76e34f3cd762034d3ed8f22398c718ca58954820a6dd3</originalsourceid><addsrcrecordid>eNpVUUtvEzEQthCIpoE7J7RCiNuG8WN3nQtSVZWCVIkLnC3XHm8cNnbq9Saq-PN4m4iHZGkO38PfzEfIGwor3gn58bjtVwdKV57JlRB0_YwsGKPrmkkBz8mCAnT1mrPuglyO4xaAcd6wl-SCtsAliGZBft04hyZX0VWo0_BYhSknn30MVXk-ZByzD1hZPOAQ9zsMT9wCJD1lTDPWp3jMmyph1snqJ60PVdJ5rHSwlS_TxJRwOGE5VgPui-sr8sLpYcTX57kkPz7ffL_-Ut99u_16fXVXG9FArq1wgLqjpmssA9GCNaZrkQvHje1aBlxYjlY6xvhamo5Koxu5boRkoFtr-ZJ8Ovnup_sdWoNz-EHtk9_p9Kii9up_JPiN6uNBCcFF2_Fi8P5kcNTB6dCrbZxSKJFVKYABNEzOp12SD-d_UnyYyuHUzo8Gh0EHjNOoWgltUzIWIpyIJsVxTOj-ZKGg5mJnX1WKVaVYNRdbJG__3eGv4NxkIbw7e25i6B98SXmvzU_nB1RUAmW8ofw38HeuyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68065239</pqid></control><display><type>article</type><title>Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Qiu, Xiao-Shan ; Huang, Ting-Ting ; Shen, Zhen-Yu ; Deng, Hui-Ying ; Ke, Zhi-Yong</creator><creatorcontrib>Qiu, Xiao-Shan ; Huang, Ting-Ting ; Shen, Zhen-Yu ; Deng, Hui-Ying ; Ke, Zhi-Yong</creatorcontrib><description>AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development．
METHODS：An IUGR rat model was established by food restriction of pregnant female rats．Fifty-six neonatal IUGR rats and 24 neonatal normal rats were randomly divided into normal control group（Cgroup），IUGR model group （scgroup），low protein diet IUGR group（SL group），and high protein diet IUGR group（SH group）．Eight rats were killed per group at wk 0，4，and 12．Serum leptin，body weight（BW），body length（BL），intestinal weight（IW），intestinal length（IL），andintestinal disaccharidase（including lactase，maltase，and saccharase） were detected．
RESULTS：BW（4．50±0．41g），BL（5．96±0．40cm），IW（0．05±0．01g），and IL（15.9±2．8cm）in neonatal IUGR rats were much lower than those in Cgroup（6．01±0．55g，6．26±0．44cm，0．10±0．02g，21.8±2．7cm，P〈0．05），while intestinal lactase and maltase activities were higher than those in Cgroup．SH group showed the fastest catch up growth and their BW，BL，IW，and IL reached the Cgroup level at wk 4．SC group showed relatively slower catch up growth than SH group，and their BW，BL，IW did not reach the Cgroup level at wk 4．SL group did not show intestine and body catch up growth．Intestinal maltase [344±33μmol／（min·q）]and saccharase activities[138±32μmol／（min·g）]in SL group were both markedly lower than nose in C group [751±102，258±271μmol／（min·g），P〈0．05]．There were no significant difierences in lactase activities at wk 4 and disaccharidase activities at wk 12 among all groups（P〈0．05）．The leptin level in SL group（0．58±0．12ng／mL） was the highest in all groups，and much lower in SH group（0．21±0．03ng／mL） than that in any other IUGR groups at wk 4（P〈0．05）．Leptin was negatively related to BW （r=-0．556，P=0．001），IW（r=-0．692，P=0．001） and IL（r=-0．738，P=0．000）at wk 4，while no correlation was found at wk 12．
CONCLUSION：High protein diet is a reasonable early nutritional mode to IUGR rats in promoting intestine and body catch up growth．</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i28.4419</identifier><identifier>PMID: 16038045</identifier><language>eng</language><publisher>United States: Pediatric Department, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China%Guangzhou Children's Hospital, Guangzhou 510120, Guangdong Province, China</publisher><subject>Animals ; Brief Reports ; Dietary Proteins - pharmacology ; Disease Models, Animal ; Female ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - diet therapy ; Fetal Growth Retardation - physiopathology ; Fetal Nutrition Disorders - blood ; Fetal Nutrition Disorders - diet therapy ; Fetal Nutrition Disorders - physiopathology ; Intestines - embryology ; Leptin - blood ; Male ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; 动物模型 ; 子宫内生长 ; 肠内营养 ; 营养学</subject><ispartof>World journal of gastroenterology : WJG, 2005-07, Vol.11 (28), p.4419-4422</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-d4f0ea71c75d20460dcc76e34f3cd762034d3ed8f22398c718ca58954820a6dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434673/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434673/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16038045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Xiao-Shan</creatorcontrib><creatorcontrib>Huang, Ting-Ting</creatorcontrib><creatorcontrib>Shen, Zhen-Yu</creatorcontrib><creatorcontrib>Deng, Hui-Ying</creatorcontrib><creatorcontrib>Ke, Zhi-Yong</creatorcontrib><title>Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development．
METHODS：An IUGR rat model was established by food restriction of pregnant female rats．Fifty-six neonatal IUGR rats and 24 neonatal normal rats were randomly divided into normal control group（Cgroup），IUGR model group （scgroup），low protein diet IUGR group（SL group），and high protein diet IUGR group（SH group）．Eight rats were killed per group at wk 0，4，and 12．Serum leptin，body weight（BW），body length（BL），intestinal weight（IW），intestinal length（IL），andintestinal disaccharidase（including lactase，maltase，and saccharase） were detected．
RESULTS：BW（4．50±0．41g），BL（5．96±0．40cm），IW（0．05±0．01g），and IL（15.9±2．8cm）in neonatal IUGR rats were much lower than those in Cgroup（6．01±0．55g，6．26±0．44cm，0．10±0．02g，21.8±2．7cm，P〈0．05），while intestinal lactase and maltase activities were higher than those in Cgroup．SH group showed the fastest catch up growth and their BW，BL，IW，and IL reached the Cgroup level at wk 4．SC group showed relatively slower catch up growth than SH group，and their BW，BL，IW did not reach the Cgroup level at wk 4．SL group did not show intestine and body catch up growth．Intestinal maltase [344±33μmol／（min·q）]and saccharase activities[138±32μmol／（min·g）]in SL group were both markedly lower than nose in C group [751±102，258±271μmol／（min·g），P〈0．05]．There were no significant difierences in lactase activities at wk 4 and disaccharidase activities at wk 12 among all groups（P〈0．05）．The leptin level in SL group（0．58±0．12ng／mL） was the highest in all groups，and much lower in SH group（0．21±0．03ng／mL） than that in any other IUGR groups at wk 4（P〈0．05）．Leptin was negatively related to BW （r=-0．556，P=0．001），IW（r=-0．692，P=0．001） and IL（r=-0．738，P=0．000）at wk 4，while no correlation was found at wk 12．
CONCLUSION：High protein diet is a reasonable early nutritional mode to IUGR rats in promoting intestine and body catch up growth．</description><subject>Animals</subject><subject>Brief Reports</subject><subject>Dietary Proteins - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - diet therapy</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Fetal Nutrition Disorders - blood</subject><subject>Fetal Nutrition Disorders - diet therapy</subject><subject>Fetal Nutrition Disorders - physiopathology</subject><subject>Intestines - embryology</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>动物模型</subject><subject>子宫内生长</subject><subject>肠内营养</subject><subject>营养学</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUUtvEzEQthCIpoE7J7RCiNuG8WN3nQtSVZWCVIkLnC3XHm8cNnbq9Saq-PN4m4iHZGkO38PfzEfIGwor3gn58bjtVwdKV57JlRB0_YwsGKPrmkkBz8mCAnT1mrPuglyO4xaAcd6wl-SCtsAliGZBft04hyZX0VWo0_BYhSknn30MVXk-ZByzD1hZPOAQ9zsMT9wCJD1lTDPWp3jMmyph1snqJ60PVdJ5rHSwlS_TxJRwOGE5VgPui-sr8sLpYcTX57kkPz7ffL_-Ut99u_16fXVXG9FArq1wgLqjpmssA9GCNaZrkQvHje1aBlxYjlY6xvhamo5Koxu5boRkoFtr-ZJ8Ovnup_sdWoNz-EHtk9_p9Kii9up_JPiN6uNBCcFF2_Fi8P5kcNTB6dCrbZxSKJFVKYABNEzOp12SD-d_UnyYyuHUzo8Gh0EHjNOoWgltUzIWIpyIJsVxTOj-ZKGg5mJnX1WKVaVYNRdbJG__3eGv4NxkIbw7e25i6B98SXmvzU_nB1RUAmW8ofw38HeuyA</recordid><startdate>20050728</startdate><enddate>20050728</enddate><creator>Qiu, Xiao-Shan</creator><creator>Huang, Ting-Ting</creator><creator>Shen, Zhen-Yu</creator><creator>Deng, Hui-Ying</creator><creator>Ke, Zhi-Yong</creator><general>Pediatric Department, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China%Guangzhou Children's Hospital, Guangzhou 510120, Guangdong Province, China</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050728</creationdate><title>Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin</title><author>Qiu, Xiao-Shan ; Huang, Ting-Ting ; Shen, Zhen-Yu ; Deng, Hui-Ying ; Ke, Zhi-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-d4f0ea71c75d20460dcc76e34f3cd762034d3ed8f22398c718ca58954820a6dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Brief Reports</topic><topic>Dietary Proteins - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - diet therapy</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Fetal Nutrition Disorders - blood</topic><topic>Fetal Nutrition Disorders - diet therapy</topic><topic>Fetal Nutrition Disorders - physiopathology</topic><topic>Intestines - embryology</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>动物模型</topic><topic>子宫内生长</topic><topic>肠内营养</topic><topic>营养学</topic><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Xiao-Shan</creatorcontrib><creatorcontrib>Huang, Ting-Ting</creatorcontrib><creatorcontrib>Shen, Zhen-Yu</creatorcontrib><creatorcontrib>Deng, Hui-Ying</creatorcontrib><creatorcontrib>Ke, Zhi-Yong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Xiao-Shan</au><au>Huang, Ting-Ting</au><au>Shen, Zhen-Yu</au><au>Deng, Hui-Ying</au><au>Ke, Zhi-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2005-07-28</date><risdate>2005</risdate><volume>11</volume><issue>28</issue><spage>4419</spage><epage>4422</epage><pages>4419-4422</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM：To investigate the intestine and body development of intrauterine growth retardation（IUGR）rats under early different protein diet and to analyze the correlation between leptin and intestine and body development．
METHODS：An IUGR rat model was established by food restriction of pregnant female rats．Fifty-six neonatal IUGR rats and 24 neonatal normal rats were randomly divided into normal control group（Cgroup），IUGR model group （scgroup），low protein diet IUGR group（SL group），and high protein diet IUGR group（SH group）．Eight rats were killed per group at wk 0，4，and 12．Serum leptin，body weight（BW），body length（BL），intestinal weight（IW），intestinal length（IL），andintestinal disaccharidase（including lactase，maltase，and saccharase） were detected．
RESULTS：BW（4．50±0．41g），BL（5．96±0．40cm），IW（0．05±0．01g），and IL（15.9±2．8cm）in neonatal IUGR rats were much lower than those in Cgroup（6．01±0．55g，6．26±0．44cm，0．10±0．02g，21.8±2．7cm，P〈0．05），while intestinal lactase and maltase activities were higher than those in Cgroup．SH group showed the fastest catch up growth and their BW，BL，IW，and IL reached the Cgroup level at wk 4．SC group showed relatively slower catch up growth than SH group，and their BW，BL，IW did not reach the Cgroup level at wk 4．SL group did not show intestine and body catch up growth．Intestinal maltase [344±33μmol／（min·q）]and saccharase activities[138±32μmol／（min·g）]in SL group were both markedly lower than nose in C group [751±102，258±271μmol／（min·g），P〈0．05]．There were no significant difierences in lactase activities at wk 4 and disaccharidase activities at wk 12 among all groups（P〈0．05）．The leptin level in SL group（0．58±0．12ng／mL） was the highest in all groups，and much lower in SH group（0．21±0．03ng／mL） than that in any other IUGR groups at wk 4（P〈0．05）．Leptin was negatively related to BW （r=-0．556，P=0．001），IW（r=-0．692，P=0．001） and IL（r=-0．738，P=0．000）at wk 4，while no correlation was found at wk 12．
CONCLUSION：High protein diet is a reasonable early nutritional mode to IUGR rats in promoting intestine and body catch up growth．</abstract><cop>United States</cop><pub>Pediatric Department, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China%Guangzhou Children's Hospital, Guangzhou 510120, Guangdong Province, China</pub><pmid>16038045</pmid><doi>10.3748/wjg.v11.i28.4419</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Brief Reports Dietary Proteins - pharmacology Disease Models, Animal Female Fetal Growth Retardation - blood Fetal Growth Retardation - diet therapy Fetal Growth Retardation - physiopathology Fetal Nutrition Disorders - blood Fetal Nutrition Disorders - diet therapy Fetal Nutrition Disorders - physiopathology Intestines - embryology Leptin - blood Male Pregnancy Rats Rats, Sprague-Dawley 动物模型 子宫内生长 肠内营养 营养学 |
| title | Effect of early nutrition on intestine development of intrauterine growth retardation in rats and its correlation to leptin |
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