N-terminal targeting of androgen receptor variant enhances response of castration resistant prostate cancer to taxane chemotherapy

Taxane-based chemotherapy is an effective treatment for castration-resistant-prostate cancer (CRPC) via stabilization of microtubules. Previous studies identified that the inhibitory effect of microtubule-targeting chemotherapy on androgen receptor (AR) activity was conferred by interfering with AR...

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Veröffentlicht in:	Molecular oncology 2015-03, Vol.9 (3), p.628-639
Hauptverfasser:	Martin, Sarah K., Banuelos, Carmen A., Sadar, Marianne D., Kyprianou, Natasha
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Androgen receptors Androgen signaling Androgens Apoptosis Binding sites Cancer therapies Castration Cell adhesion & migration Cell culture Cell cycle Chemotherapy Cytoskeleton Epithelial cells Epithelial-mesenchymal transition FDA approval Ligands Localization Medical research Mesenchyme Metastasis Microtubules Mutation Nuclear transport Polymerization Prostate cancer Taxanes Therapeutic resistance Transcription Tubulin Tumors
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