A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes

Obesity and diabetes are among the greatest risk factors for infection following total joint arthroplasty. However, the underlying mechanism of susceptibility is unclear. We compared orthopedic implant-associated Staphylococcus aureus infections in type 1 (T1D) versus type 2 (T2D) diabetic mouse mod...

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Veröffentlicht in:	Infection and immunity 2015-06, Vol.83 (6), p.2264-2274
Hauptverfasser:	Farnsworth, Christopher W, Shehatou, Cindy T, Maynard, Robert, Nishitani, Kohei, Kates, Stephen L, Zuscik, Michael J, Schwarz, Edward M, Daiss, John L, Mooney, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Bacterial Infections Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 - immunology Glucose Intolerance Humans Immunity, Humoral Male Mice Mice, Inbred C57BL Obesity - chemically induced Obesity - immunology Osteomyelitis - microbiology Staphylococcal Infections - microbiology Staphylococcus aureus
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