Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility

We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel. All mutations detected were outside hot spot (HS) regions. The F1386S mutation detected in a...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-06, Vol.59 (6), p.3570-3573
Hauptverfasser:	Martí-Carrizosa, M, Sánchez-Reus, F, March, F, Cantón, E, Coll, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents Antifungal Agents - pharmacology Candida Candida - drug effects Candida - genetics Candida parapsilosis Drug Resistance, Fungal - genetics Echinocandins Echinocandins - pharmacology Fungal Proteins - genetics Mechanisms of Resistance Mutation
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