ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus
The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2015-06, Vol.59 (6), p.3611-3614 |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Vimberg, Vladimir Lenart, Jakub Janata, Jiri Balikova Novotna, Gabriela |
| description | The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance were observed in a clpP knockout strain expressing msr(A), demonstrating that ClpX affects Msr(A) independently of ClpP. |
| doi_str_mv | 10.1128/AAC.04367-14 |
| format | Article |
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Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. 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All Rights Reserved.</rights><rights>Copyright © 2015, American Society for Microbiology. All Rights Reserved. 2015 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a451t-baf3fe40548ac9b31e7993d0e6877fd99e36bddcf750d0b728e4da2c07f3315e3</citedby><cites>FETCH-LOGICAL-a451t-baf3fe40548ac9b31e7993d0e6877fd99e36bddcf750d0b728e4da2c07f3315e3</cites><orcidid>0000-0002-5464-4763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432155/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432155/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25801573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vimberg, Vladimir</creatorcontrib><creatorcontrib>Lenart, Jakub</creatorcontrib><creatorcontrib>Janata, Jiri</creatorcontrib><creatorcontrib>Balikova Novotna, Gabriela</creatorcontrib><title>ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance were observed in a clpP knockout strain expressing msr(A), demonstrating that ClpX affects Msr(A) independently of ClpP.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Ketolides</subject><subject>Ketolides - pharmacology</subject><subject>Macrolides - pharmacology</subject><subject>Mechanisms of Resistance</subject><subject>Mutation</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - metabolism</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9rFDEUx4NY7Lp68yw5tuC0yeTXzEVYFrVCSwUVvIVM5sVNmUnGZMay_71ptxY9iJc8kvfJh7x8EXpFyRmldXO-2WzPCGdSVZQ_QStK2qaSopVP0YoQKSveEH6Mnud8Q8petOQZOq5FQ6hQbIVut8P0qfKhhwnKEmbslmBnHwOODpfmN-zDDMlBgoxv_bzDMwylpDjurQ-4HPs8m2AB2xgKlqDH3R5f5XSyOS2X8efZTLv9EG20dsnYLAmW_AIdOTNkePlQ1-jr-3dfthfV5fWHj9vNZWW4oHPVGccccCJ4Y2zbMQqqbVlPQDZKub5tgcmu761TgvSkU3UDvDe1JcoxRgWwNXp78E5LN0Jvy4TJDHpKfjRpr6Px-u9O8Dv9Pf7UnLOaClEEJw-CFH8skGc9-mxhGEyAuGRNFaG8YaqW_0dlQ2spVVGv0ZsDalPMOYF7fBEl-i5WXWLV97FqeoefHnCTx1rfxCWF8mn_Yl__OfGj-Hfm7Be0N6zs</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Vimberg, Vladimir</creator><creator>Lenart, Jakub</creator><creator>Janata, Jiri</creator><creator>Balikova Novotna, Gabriela</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5464-4763</orcidid></search><sort><creationdate>20150601</creationdate><title>ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus</title><author>Vimberg, Vladimir ; 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Ketolides Ketolides - pharmacology Macrolides - pharmacology Mechanisms of Resistance Mutation Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism |
| title | ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus |
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