Global low-frequency motions in protein allostery: CAP as a model system

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. There is considerable evidence that allosteric cooperativity can be communicated by the modulation of protein dynamics without conformational change. The Catabolite Activator Protein (CAP)...

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Veröffentlicht in:Biophysical reviews 2015, Vol.7 (2), p.175-182
Hauptverfasser: Townsend, Philip D., Rodgers, Thomas L., Pohl, Ehmke, Wilson, Mark R., McLeish, Tom C. B., Cann, Martin J.
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Sprache:eng
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