Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma

Purpose: Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival, and are targets of drugs in clinical development. We assessed expression of PI3K in melanomas and nevi, and studied associations between PI3K pathway members an...

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Veröffentlicht in:	Clinical cancer research 2009-05, Vol.15 (9), p.3029-3036
Hauptverfasser:	AZIZ, Saadia A, DAVIES, Michael, PICK, Elah, ZITO, Christopher, JILAVEANU, Lucia, CAMP, Robert L, RIMM, David L, KLUGER, Yuval, KLUGER, Harriet M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Brain Neoplasms - secondary Cell Proliferation Chromones - pharmacology Dermatology Enzyme Inhibitors - pharmacology Humans Immunoblotting Immunoenzyme Techniques Medical sciences melanoma Melanoma - drug therapy Melanoma - enzymology Melanoma - pathology Morpholines - pharmacology Nevus, Pigmented - drug therapy Nevus, Pigmented - enzymology Nevus, Pigmented - pathology Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Phosphorylation - immunology PI3K predictive markers Protein Array Analysis Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Skin Neoplasms - secondary Tissue Array Analysis Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions
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