Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion

LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and breast cancer progression. However, little work has been done on the roles of LKB1 in ce...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2014-09, Vol.33 (1), p.70-70, Article 70
Hauptverfasser:	Li, Juan, Liu, Jie, Li, Pingping, Mao, Xiaona, Li, Wenjie, Yang, Jin, Liu, Peijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Case-Control Studies Cell adhesion & migration Cell Movement Cell Polarity Development and progression Down-Regulation Epithelial Cells - enzymology Epithelial Cells - pathology Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genetic aspects Humans Kinases Mammary Glands, Human - enzymology Mammary Glands, Human - pathology MCF-7 Cells Middle Aged Mutation Neoplasm Invasiveness Phenotype Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA Interference Signal Transduction Transfection
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