Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase Expression

Estrogens dramatically dilate numerous vascular beds with the greatest response in the uterus. Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). We hypo...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2015-06, Vol.156 (6), p.2288-2298
Hauptverfasser:	Lechuga, Thomas J, Zhang, Hong-hai, Sheibani, Lili, Karim, Muntarin, Jia, Jason, Magness, Ronald R, Rosenfeld, Charles R, Chen, Dong-bao
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Biosynthesis Carotid arteries Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid artery Cystathionine b-synthase Cystathionine beta-Synthase - genetics Cystathionine beta-Synthase - metabolism Cystathionine g-lyase Endothelium Estradiol - pharmacology Estrogen Replacement Therapy Estrogens Female Gene expression Hormone replacement therapy Hydrogen sulfide Hydrogen Sulfide - metabolism Immunofluorescence Localization Methylene blue Microscopy, Fluorescence mRNA Muscles Original Research Ovariectomy Post-menopause Protein expression Proteins Sex hormones Sheep Smooth muscle Therapy Uterine Artery - metabolism Uterus Vasodilation Womens health
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