The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia

The eukaryotic translation initiation factor eIF4E is a potent oncogene elevated in many cancers, including the M4 and M5 subtypes of acute myeloid leukemia (AML). Although eIF4E RNA levels are elevated 3- to 10-fold in M4/M5 AML, the molecular underpinnings of this dysregulation were unknown. Here,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2013-10, Vol.27 (10), p.2047-2055
Hauptverfasser:	Hariri, F, Arguello, M, Volpon, L, Culjkovic-Kraljacic, B, Nielsen, T H, Hiscott, J, Mann, K K, Borden, K L B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/45/612/822 692/699/67/1990/283/1897 Acute myeloid leukemia B-Lymphocytes - cytology B-Lymphocytes - metabolism Cancer Cancer Research Case-Control Studies Cell Nucleus - genetics Cells, Cultured Critical Care Medicine Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Gene Expression Regulation, Leukemic Genetic aspects Genetic transcription Health aspects Hematology Humans Initiation factor eIF-4E Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Lymphocytes B Medicine Medicine & Public Health NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Oncogenes Oncology original-article Physiological aspects Promoter Regions, Genetic - genetics Proteins Ribonucleic acid RNA Transcription activation Transcriptional Activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!