Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

The repressive Hippo pathway has a profound tumour suppressive role in cancer by restraining the growth-promoting function of the transcriptional coactivator, YAP. We previously showed that the stem cell transcription factor Sox2 maintains cancer stem cells (CSCs) in osteosarcomas. We now report tha...

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Veröffentlicht in:	Nature communications 2015-04, Vol.6 (1), p.6411-6411, Article 6411
Hauptverfasser:	Basu-Roy, Upal, Bayin, N. Sumru, Rattanakorn, Kirk, Han, Eugenia, Placantonakis, Dimitris G., Mansukhani, Alka, Basilico, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 13/109 13/51 13/89 13/95 14 14/34 14/63 631/45/612/822 631/67/1344 631/67/71 631/80/83/2360 96 96/100 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Cell Line, Tumor Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - metabolism Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism multidisciplinary Neoplastic Stem Cells - metabolism Neurofibromin 2 - genetics Neurofibromin 2 - metabolism Osteosarcoma - genetics Osteosarcoma - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Science Science (multidisciplinary) Signal Transduction SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Transcription Factors
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