Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids : in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei

The polyunsaturated fatty acids docosahexaenoic acid (C22:6,n-3), eicosapentaenoic acid, arachidonic acid, and linoleic acid caused marked in vitro growth inhibition of Plasmodium falciparum, assessed by a radiometric assay. In contrast, negligible parasite killing was seen with oleic acid or docosa...

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Veröffentlicht in:	The Journal of clinical investigation 1992-03, Vol.89 (3), p.961-967
Hauptverfasser:	KUMARATILAKE, L. M, ROBINSON, B. S, FERRANTE, A, POULOS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Antioxidants - pharmacology Biological and medical sciences Fatty Acids, Unsaturated - pharmacology Female Fish Oils - pharmacology Human protozoal diseases Infectious diseases Malaria Malaria - drug therapy Medical sciences Mice Mice, Inbred BALB C Oxidation-Reduction Parasitic diseases Plasmodium berghei - drug effects Plasmodium falciparum - drug effects Protozoal diseases
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