chronobiology, etiology and pathophysiology of obesity
The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase...
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| Veröffentlicht in: | International Journal of Obesity 2010-12, Vol.34 (12), p.1667-1683 |
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| description | The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. Finally, ideas about the use of chronobiology in the treatment of obesity are discussed. Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity. |
| doi_str_mv | 10.1038/ijo.2010.118 |
| format | Article |
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Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. 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Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2010.118</identifier><identifier>PMID: 20567242</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/1385 ; 631/443/319 ; 692/699/2743/393 ; 692/700/565 ; Aging ; Animal models ; Animals ; Biological and medical sciences ; Biology ; Cardiovascular diseases ; Causes and theories of causation ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian Rhythm - physiology ; Circadian rhythms ; CLOCK Proteins - genetics ; CLOCK Proteins - physiology ; Cognitive ability ; Development and progression ; Diseases ; Dyslipidemias ; Energy Intake - physiology ; Epidemiology ; Etiology ; Exercise ; Feeding Behavior - physiology ; Food ; Genes ; Genetic aspects ; Health Promotion and Disease Prevention ; Humans ; Hypertension ; Hypothalamus ; Internal Medicine ; Light ; Management ; Medical sciences ; Medicine ; Medicine & Public Health ; Melatonin ; Metabolic Diseases ; Metabolic syndrome ; Mice ; Miscellaneous ; Motor Activity - physiology ; Nutrition research ; Obesity ; Obesity - etiology ; Obesity - physiopathology ; Other metabolic disorders ; Pacemakers ; Pathophysiology ; Patient outcomes ; Physiological aspects ; Physiology ; Public Health ; review ; Risk factors ; Shift work ; Sleep - physiology ; Sleep Deprivation - complications ; Sleep Deprivation - genetics ; Sleep Deprivation - physiopathology ; Type 2 diabetes</subject><ispartof>International Journal of Obesity, 2010-12, Vol.34 (12), p.1667-1683</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2010</rights><rights>2010 Macmillan Publishers Limited All rights reserved 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-97bff03e08f7a2c7786530679ddc7a7a3560f2b3b6bb325e0bb40f398bd319553</citedby><cites>FETCH-LOGICAL-c699t-97bff03e08f7a2c7786530679ddc7a7a3560f2b3b6bb325e0bb40f398bd319553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2010.118$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2010.118$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23619361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20567242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garaulet, M</creatorcontrib><creatorcontrib>Ordovás, J.M</creatorcontrib><creatorcontrib>Madrid, J.A</creatorcontrib><title>chronobiology, etiology and pathophysiology of obesity</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. Finally, ideas about the use of chronobiology in the treatment of obesity are discussed. Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity.</description><subject>631/378/1385</subject><subject>631/443/319</subject><subject>692/699/2743/393</subject><subject>692/700/565</subject><subject>Aging</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Cardiovascular diseases</subject><subject>Causes and theories of causation</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>CLOCK Proteins - genetics</subject><subject>CLOCK Proteins - physiology</subject><subject>Cognitive ability</subject><subject>Development and progression</subject><subject>Diseases</subject><subject>Dyslipidemias</subject><subject>Energy Intake - physiology</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Exercise</subject><subject>Feeding Behavior - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garaulet, M</au><au>Ordovás, J.M</au><au>Madrid, J.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>chronobiology, etiology and pathophysiology of obesity</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>34</volume><issue>12</issue><spage>1667</spage><epage>1683</epage><pages>1667-1683</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>The effect of CD on human health is an emerging issue. 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| subjects | 631/378/1385 631/443/319 692/699/2743/393 692/700/565 Aging Animal models Animals Biological and medical sciences Biology Cardiovascular diseases Causes and theories of causation Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm - physiology Circadian rhythms CLOCK Proteins - genetics CLOCK Proteins - physiology Cognitive ability Development and progression Diseases Dyslipidemias Energy Intake - physiology Epidemiology Etiology Exercise Feeding Behavior - physiology Food Genes Genetic aspects Health Promotion and Disease Prevention Humans Hypertension Hypothalamus Internal Medicine Light Management Medical sciences Medicine Medicine & Public Health Melatonin Metabolic Diseases Metabolic syndrome Mice Miscellaneous Motor Activity - physiology Nutrition research Obesity Obesity - etiology Obesity - physiopathology Other metabolic disorders Pacemakers Pathophysiology Patient outcomes Physiological aspects Physiology Public Health review Risk factors Shift work Sleep - physiology Sleep Deprivation - complications Sleep Deprivation - genetics Sleep Deprivation - physiopathology Type 2 diabetes |
| title | chronobiology, etiology and pathophysiology of obesity |
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