Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic and endo...

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Veröffentlicht in:	Nature communications 2015-05, Vol.6 (1), p.7007-7007, Article 7007
Hauptverfasser:	Mauvezin, Caroline, Nagy, Péter, Juhász, Gábor, Neufeld, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/19 14/28 14/35 631/80/39/2346 631/80/642/1624 631/80/642/2384 631/80/86 64 64/24 96 Acids - metabolism Animals Autophagy - drug effects Drosophila melanogaster - drug effects Drosophila melanogaster - enzymology Humanities and Social Sciences Lysosomes - drug effects Lysosomes - metabolism Lysosomes - ultrastructure Macrolides - pharmacology Membrane Fusion - drug effects Models, Biological multidisciplinary Phagosomes - drug effects Phagosomes - metabolism Phagosomes - ultrastructure Protein Subunits - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Science Science (multidisciplinary) Vacuolar Proton-Translocating ATPases - metabolism
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