RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

We have ablated the cellular RNA degradation machinery in differentiated B cells and pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and nuclear RNase (Exosc10) components of RNA exosome and identified a vast number of long non-coding RNAs (lncRNAs) and enhancer R...

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Veröffentlicht in:	Cell 2015-05, Vol.161 (4), p.774-789
Hauptverfasser:	Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, James E., Rabadan, Raul, Basu, Uttiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - metabolism DNA embryonic stem cells Embryonic Stem Cells - metabolism Enhancer Elements, Genetic Exosome Multienzyme Ribonuclease Complex - metabolism exosomes Gene Expression Regulation Genomic Instability Heterochromatin - metabolism hybrids Immunoglobulin Class Switching Immunoglobulin Heavy Chains - genetics Mice mutagenesis non-coding RNA Regulatory Sequences, Nucleic Acid ribonucleases RNA, Long Noncoding - metabolism
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