Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

Self-aggregation of the microtubule-binding protein Tau reduces its functionality and is tightly associated with Tau-related diseases, termed tauopathies. Tau aggregation is also strongly associated with two nucleating six-residue segments, namely PHF6 (VQIVYK) and PHF6* (VQIINK). In this paper, usi...

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Veröffentlicht in:	The journal of physical chemistry. B 2015-04, Vol.119 (13), p.4582-4593
Hauptverfasser:	Ganguly, Pritam, Do, Thanh D, Larini, Luca, LaPointe, Nichole E, Sercel, Alexander J, Shade, Madeleine F, Feinstein, Stuart C, Bowers, Michael T, Shea, Joan-Emma
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Aggregates Benzothiazoles Dimerization Diseases Fragments Humans Ion exchangers Mass Spectrometry Mathematical models Microscopy, Electron, Transmission microtubules Molecular dynamics Molecular Dynamics Simulation mutants Mutation Protein Binding Self assembly tau Proteins - chemistry tau Proteins - genetics Thiazoles - chemistry transmission electron microscopy
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