Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited

We have investigated the role of leukocyte-endothelial cell interactions in a rabbit model of hemorrhagic vasculitis. Microvascular injury was produced in the skin by intradermal injection of Salmonella typhosa endotoxin followed 20 h later by intravenous zymosan, which activates complement. Hemorrh...

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Veröffentlicht in:	The Journal of clinical investigation 1992-01, Vol.89 (1), p.259-272
Hauptverfasser:	Argenbright, L W, Barton, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antigens, CD - immunology Bacterial Toxins - pharmacology Blood Vessels - drug effects Blood Vessels - pathology Cell Adhesion - physiology Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Adhesion Molecules - toxicity Complement Activation Disease Models, Animal Endotoxins Enterotoxins - pharmacology Female Hemorrhage Integrins - metabolism Intercellular Adhesion Molecule-1 Leukocytes - metabolism Models, Biological Purpura, Schoenlein-Henoch - chemically induced Purpura, Schoenlein-Henoch - metabolism Purpura, Schoenlein-Henoch - therapy Rabbits Skin - drug effects Skin - pathology Zymosan - pharmacology
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